Editors: Somchai Chutipongtanate, Suradej Hongeng

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine

eBook: US $89 Special Offer (PDF + Printed Copy): US $107
Printed Copy: US $152
Library License: US $356
ISBN: 978-981-5036-76-2 (Print)
ISBN: 978-981-5036-75-6 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150367561210101

Introduction

Precision medicine is a disruptive innovation with a fast-evolving pace in the healthcare ecosystem. Precision medicine enables precise diagnosis and targeted treatment by considering individual variability in the abnormalities of causative genes and molecular drivers behind biochemical mechanisms. A vast amount of data created by advanced omics technologies is a foundation of precision medicine’s success, and the implications of the findings from these technologies can potentially improve clinical outcomes.

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine presents essential information of molecular and translational research in precision medicine, with a specific focus on pediatrics. This book provides an accessible introduction to omics technologies, gives a detailed explanation of bioinformatics workflows to interpret high-throughput omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Contributions to the book have been provided by experts in biomedical engineering and clinical practice, thus, bringing an informed perspective to the reader on each topic. The book is a valuable resource for postgraduate students, researchers, data scientists and clinicians interested in precision medicine, as well as researchers in the field of genetics and pediatrics who are interested in understanding the role of precision medicine in clinical practice.

Audience: Postgraduate researchers and professionals in the field of precision medicine and pediatrics; Data scientists working in medical informatics.

Foreword

- Pp. i
Ampaiwan Chuansumrit
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Preface

- Pp. ii
Somchai Chutipongtanate, Suradej Hongeng
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List of Contributors

- Pp. iii-iv (2)

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Translational Research in Pediatric Precision Medicine

- Pp. 1-16 (16)
Somchai Chutipongtanate*, Suradej Hongeng*
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Bioinformatics in Precision Medicine

- Pp. 17-42 (26)
James Reigle, Phillip J. Dexheimer, Behrouz Shamsaei, Alexander Thorman, Somchai Chutipongtanate*, Jarek Meller*
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Artificial Intelligence in Medicine

- Pp. 43-57 (15)
Danai Khemasuwan*
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Using Next Generation Sequencing for Diagnosis of Suspected Genetic Disorders

- Pp. 58-67 (10)
Parith Wongkittichote, Pisut Pongchaikul, Duangrurdee Wattanasirichaigoon*
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Pharmacogenomics and Perioperative Translational Medicine

- Pp. 68-92 (25)
Sirirat Rattana-arpa, Patcharee Sriswasdi*
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Proteomics: Moving Toward Precision Medicine

- Pp. 93-117 (25)
Somchai Chutipongtanate*, Pankaj Dwivedi
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Metabolomics and Precision Medicine

- Pp. 118-133 (16)
James Reigle*, Khyati Mehta, Somchai Chutipongtanate
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Genetically Modified Hematopoietic Stem Cells for Gene Therapy in Beta-Thalassemia: Power of Viral Vector Towards Clinical Application

- Pp. 134-144 (11)
Kanit Bhukhai, Suparerk Bowornpinyo, Suradej Hongeng*
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Molecular Therapeutic Approach Focusing on Kinases

- Pp. 145-167 (23)
Pankaj Dwivedi, Somchai Chutipongtanate*
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Membrane Attacking Peptides: A New Involving Cancer Therapy

- Pp. 168-192 (25)
Wararat Chiangjong, Suradej Hongeng, Somchai Chutipongtanate*
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Chimeric Antigen Receptor (CAR) T Cell for Pediatric Solid Tumors: The Next Frontier in Cancer Treatment

- Pp. 193-224 (32)
Thitinee Vanichapol, Somchai Chutipongtanate, Usanarat Anurathapan, Suradej Hongeng*
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Hematopoietic Stem Cell Transplant in Inherited Genetic Diseases

- Pp. 225-234 (10)
Usanarat Anurathapan*, Suradej Hongeng
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Subject Index

- Pp. 235-241 (7)

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