Editors: Somchai Chutipongtanate, Suradej Hongeng

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $118
Library License: US $356
ISBN: 978-981-5036-76-2 (Print)
ISBN: 978-981-5036-75-6 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150367561210101

Introduction

Precision medicine is a disruptive innovation with a fast-evolving pace in the healthcare ecosystem. Precision medicine enables precise diagnosis and targeted treatment by considering individual variability in the abnormalities of causative genes and molecular drivers behind biochemical mechanisms. A vast amount of data created by advanced omics technologies is a foundation of precision medicine’s success, and the implications of the findings from these technologies can potentially improve clinical outcomes.

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine presents essential information of molecular and translational research in precision medicine, with a specific focus on pediatrics. This book provides an accessible introduction to omics technologies, gives a detailed explanation of bioinformatics workflows to interpret high-throughput omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Contributions to the book have been provided by experts in biomedical engineering and clinical practice, thus, bringing an informed perspective to the reader on each topic. The book is a valuable resource for postgraduate students, researchers, data scientists and clinicians interested in precision medicine, as well as researchers in the field of genetics and pediatrics who are interested in understanding the role of precision medicine in clinical practice.

Audience: Postgraduate researchers and professionals in the field of precision medicine and pediatrics; Data scientists working in medical informatics.

Preface

Molecular and Translational Medicine is an evolving concept of addressing unmet clinical needs by generating laboratory testable hypotheses grounded on knowledge and technical advancement in molecular biology, eventually translated into the development of promising and practical diagnostic tools or new therapeutics for human diseases. Recognizing that there are variabilities between individuals and knowing that one disease phenotype can be driven by different molecular errors and varying mechanisms, effective therapy in one person may have fewer effects on others. Precision medicine aims to identify patient sub-populations that will benefit from one treatment and prevent harmful side effects in other populations by advanced diagnostic platforms such as next-generation sequencing and pharmacogenomics. On the other hand, identifying molecular errors or mechanisms shared by different diseases can give insights into new therapeutic approaches or repurposing of known drugs. Targeting responsible molecules and druggable genomic alterations to manipulate disease processes can yield better outcomes due to improved treatment responses, reduced side effects and cost-effectiveness for the whole healthcare system.

Accordingly, this eBook entitled “Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine” provides an accessible introduction to Omics technologies; it gives a detailed explanation of bioinformatic workflows to interpret high-throughput Omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Each chapter was written by skilled scientists and clinicians who are actively working in their fields. This eBook, therefore, serves as a useful resource for postgraduate students, researchers, and clinicians who are interested in precision medicine.

The cover page aims to illustrate the connection of Omics to precise diagnosis and treatment. We want to thank Dr. Marin Satawiriya for her invaluable contribution to this cover design



Somchai Chutipongtanate
Acting Director, Pediatric Translational Research Unit
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital
Mahidol University, Bangkok
Thailand

&

Suradej Hongeng
Professor and Head of Division of Hematology and Oncology
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital
Mahidol University, Mahidol University
Bangkok
Thailand