Editor: Muhammad Sarwar Khan

Series Title: Frontiers in Protein and Peptide Sciences

Frontiers in Molecular Pharming

Volume 2

eBook: US $89 Special Offer (PDF + Printed Copy): US $152
Printed Copy: US $107
Library License: US $356
ISSN: 2589-2924 (Print)
ISSN: 2213-9877 (Online)
ISBN: 978-981-5036-67-0 (Print)
ISBN: 978-981-5036-66-4 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150366641210201

Introduction

The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming.

Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters.

Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Audience: Researchers and students of biochemistry, molecular biology, and biotechnology.

Contributors

Editor(s):
Muhammad Sarwar Khan
Centre of Agricultural Biochemistry and Biotechnology (CABB)
University of Agriculture
Faisalabad
Pakistan




Contributor(s):
Aamir Shehzad
Drug Discovery and Structural Biology Group, Health Biotechnology Division
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan
/
Pakistan Institute of Engineering and Applied Sciences (PIEAS)
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan


Adnan K. Niazi
Centre of Agricultural Biochemistry and Biotechnology (CABB)
University of Agriculture Faisalabad
Faisalabad, 38040
Pakistan


Aisha Mahmood
Department of Physiology, Faculty Of Veterinary And Animal Sciences
The Islamia University of Bahawalpur
Bahawalpur
Pakistan


Aisha Tarar
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Amjad Ali
Atta-ur-Rahman School of Applied Biosciences (ASAB)
National University of Sciences and Technology (NUST)
Islamabad
Pakistan


Amjad Islam Aqib
Department of Medicine, Faculty of Veterinary Science
Cholistan University of Veterinary and Animal Sciences
Bahawalpur, 63100
Pakistan


Amna Bari
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics
Huazhong Agricultural University
Wuhan
P. R. China


Amna Ramzan
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Anam Naz
Institute of Molecular Biology and Biotechnology
The University of Lahore
Lahore
Pakistan


Ayesha Siddiqui
Agricultural Biotechnology Division
National Institute for Biotechnology & Genetic Engineering (NIBGE)
Jhang Road, Faisalabad, 38000
Pakistan
/
Department of Biotechnology
Pakistan Institute of Engineering and Applied Sciences(PIEAS)
Nilore, Islamabad
Pakistan


Barira Zahid
Key Laboratory of Horticultural Plant Biology (Ministry of Education)
College of Horticulture and Forestry, Huazhong Agricultural University
Wuhan
P. R. China


Bushra Rashid
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Faisal Siddique
Department of Microbiology, Faculty of Veterinary Science
Cholistan University of Veterinary and Animal Sciences
Bahawalpur, 63100
Pakistan


Faiz Ahmad Joyia
Centre of Agricultural Biochemistry & Biotechnology (CABB)
University of Agriculture
Faisalabad
Pakistan


Farah Shahid
Department of Bioinformatics and Biotechnology
Government College University Faisalabad
Faisalabad
Pakistan


Fatima Ijaz
Department of Biochemistry, Faculty of Biological Sciences
Quaid-i-Azam University
Islamabad
Pakistan


Fatima Khalid
Key Laboratory of Horticultural Plant Biology (Ministry of Education)
College of Horticulture and Forestry, Huazhong Agricultural University
Wuhan
P. R. China


Feng Xing
College of Life Science
Xinyang Normal University
Xinyang 464000
P. R. China


Ghulam Mustafa
Centre of Agricultural Biochemistry & Biotechnology (CABB)
University of Agriculture
Faisalabad
Pakistan


Huma Shakoor
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Iqra Arshad
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Iqra Mehmood
Department of Bioinformatics and Biotechnology
Government College University Faisalabad
Faisalabad
Pakistan


Iqra Muzammil
Department of Veterinary Medicine, Faculty of Veterinary Science
University of Veterinary and Animal Sciences
Lahore, 54000
Pakistan


Jia-Ming Song
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources
College of Life Science and Technology, Guangxi University
Nanning
P. R. China
/
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics
Huazhong Agricultural University
Wuhan
P. R. China


Kiran Saba
Department of Biochemistry, Faculty of Biological Sciences
Quaid-i-Azam University
Islamabad
Pakistan


Kishver Tusleem
Sir Ganga Ram Hospital
Fatima Jinnah Medical University
Lahore
Pakistan


Ling-Ling Chen
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources
College of Life Science and Technology, Guangxi University
Nanning
P. R. China
/
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics
Huazhong Agricultural University
Wuhan
P. R. China


Majid Ali Shah
Drug Discovery and Structural Biology Group, Health Biotechnology Division
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan
/
Pakistan Institute of Engineering and Applied Sciences (PIEAS)
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan


Maryam Zafar
Drug Discovery and Structural Biology Group, Health Biotechnology Division
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan
/
Pakistan Institute of Engineering and Applied Sciences (PIEAS)
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan


Mazhar Iqbal
Drug Discovery and Structural Biology Group, Health Biotechnology Division
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan
/
Pakistan Institute of Engineering and Applied Sciences (PIEAS)
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan


Moazur Rahman
Drug Discovery and Structural Biology Group, Health Biotechnology Division
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan
/
School of Biological Sciences
University of the Punjab
Lahore
Pakistan


Mohammad Tahir Waheed
Department of Biochemistry, Faculty of Biological Sciences
Quaid-i-Azam University
Islamabad
Pakistan


Mohsin Khurshid
Department of Microbiology
Government College University
Faisalabad
Pakistan


Mubashrah Mahmood
Department of Theriogenology, Faculty of Veterinary Science
University of Agriculture
Faisalabad, 38000
Pakistan


Muhammad Aamir Naseer
Department of Clinical Medicine and Surgery, Faculty of Veterinary Science
University of Agriculture
Faisalabad, 38000
Pakistan


Muhammad Omar Khan
Agricultural Biotechnology Division
National Institute for Biotechnology & Genetic Engineering (NIBGE)
Jhang Road, Faisalabad, 38000
Pakistan
/
Department of Biotechnology
Pakistan Institute of Engineering and Applied Sciences(PIEAS)
Nilore, Islamabad
Pakistan


Muhammad Sameeullah
Innovative Food Technologies Development Application and Research Center, Faculty of Engineering
Bolu Abant Izzet Baysal University
14030, Bolu
Turkey


Muhammad Sarwar Khan
Center of Agricultural Biochemistry and Biotechnology
University of Agriculture
Faisalabad
Pakistan


Muhammad Shareef Masoud
Department of Bioinformatics and Biotechnology
Government College University
Faisalabad
Pakistan


Muhammad Shoaib
Institute of Microbiology, Faculty of Veterinary Science
University of Agriculture
Faisalabad, 38000
Pakistan


Muhammad Qasim
Department of Bioinformatics and Biotechnology
Government College University
Faisalabad
Pakistan


Muhammad Suleman Malik
Department of Biochemistry, Faculty of Biological Sciences
Quaid-i-Azam University
Islamabad
Pakistan


Muhammad Tahir ul Qamar
College of Life Science and Technology
Guangxi University
Nanning
P. R. China


Nazia Nahid
Department of Bioinformatics and Biotechnology
Government College University
Faisalabad
Pakistan


Niaz Ahmad
Agricultural Biotechnology Division
National Institute for Biotechnology & Genetic Engineering (NIBGE)
Jhang Road, Faisalabad, 38000
Pakistan
/
Department of Biotechnology
Pakistan Institute of Engineering and Applied Sciences(PIEAS)
Nilore, Islamabad
Pakistan


Phetole Mangena
Department of Biodiversity, School of Molecular and Life Sciences, Faculty of Science and Agriculture
University of Limpopo
Private Bag X1106, Sovenga 0727
Republic of South Africa


Phumzile Mkhize
Department of Microbiology, Biochemistry and Biotechnology
School of Molecular and Life Sciences, Faculty of Science and Agriculture, University of Limpopo
Private Bag X1106, Sovenga 0727
Republic of South Africa


Rabia Abbas
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Rimsha Riaz
Center of Agricultural Biochemistry and Biotechnology (CABB)
University of Agriculture
Faisalabad – 38040
Pakistan


Saad Ahmad
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
Lanzhou
China


Saba Altaf
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Saher Qadeer
Center of Agricultural Biochemistry and Biotechnology (CABB)
University of Agriculture
Faisalabad – 38040
Pakistan


Sajjad Ahmad
Department of Health and Biological Sciences
Abasyn University
Peshawar
Pakistan


Samman Munir
Department of Bioinformatics and Biotechnology
Government College University
Faisalabad
Pakistan


Sara Latif
Department of Biochemistry, Faculty of Biological Sciences
Quaid-i-Azam University
Islamabad
Pakistan


Soban Tufail
Drug Discovery and Structural Biology Group, Health Biotechnology Division
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan
/
Pakistan Institute of Engineering and Applied Sciences (PIEAS)
National Institute for Biotechnology and Genetic Engineering (NIBGE)
Faisalabad
Pakistan


Sumera Rashid
Centre of Excellence in Molecular Biology
University of the Punjab
Lahore
Pakistan


Syed Farhat Ali
School of Life Sciences
Forman Christian College (A Chartered University)
Lahore
Pakistan


Tean Zaheer
Department of Parasitology, Faculty of Veterinary Science
University of Agriculture
Faisalabad, 38000
Pakistan


Usman Ali Ashfaq
Department of Bioinformatics and Biotechnology
Government College University Faisalabad
Faisalabad
Pakistan


Xitong Zhu
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics
Huazhong Agricultural University
Wuhan
P. R. China


Zainab Y. Sandhu
Montclair State University
New Jersey NJ 07043
USA


Zeshan Haider
Centre of Agricultural Biochemistry and Biotechnology (CABB)
University of Agriculture Faisalabad
Faisalabad, 38040
Pakistan
/
State Key Laboratory of Grassland Agro-Ecosystems
College of Pastoral Agriculture Science and Technology, Lanzhou University
Lanzhou
China