Editor: Muhammad Sarwar Khan

Series Title: Frontiers in Protein and Peptide Sciences

Frontiers in Molecular Pharming

Volume 2

eBook: US $89 Special Offer (PDF + Printed Copy): US $152
Printed Copy: US $107
Library License: US $356
ISSN: 2589-2924 (Print)
ISSN: 2213-9877 (Online)
ISBN: 978-981-5036-67-0 (Print)
ISBN: 978-981-5036-66-4 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150366641210201


The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming.

Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters.

Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Audience: Researchers and students of biochemistry, molecular biology, and biotechnology.


- Pp. i-ii (2)
Muhammad Sarwar Khan
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List of Contributors

- Pp. iii-vi (4)

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Tools for Prediction and Validation of Epitopic Regions on Protein Targets for Vaccine Development and Diagnostics

- Pp. 1-29 (29)
Soban Tufail, Majid Ali Shah, Maryam Zafar, Mazhar Iqbal, Amjad Ali, Aamir Shehzad*, Moazur Rahman*
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Immunoinformatics and its Role in Vaccine Development

- Pp. 30-65 (36)
Iqra Mehmood, Amna Bari, Sajjad Ahmad, Anam Naz, Farah Shahid, Usman Ali Ashfaq, Kishver Tusleem, Muhammad Tahir ul Qamar*
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Computational Toolbox for Analysis of Protein Thermostability

- Pp. 66-80 (15)
Syed Farhat Ali*
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Pan-Proteomics to Analyze the Functional Complexity of Organisms

- Pp. 81-98 (18)
Muhammad Tahir ul Qamar, Barira Zahid, Fatima Khalid, Anam Naz, Jia-Ming Song, Sajjad Ahmad, Xitong Zhu, Feng Xing, Muhammad Sarwar Khan, Ling-Ling Chen*
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Functional Characterization of Proteins and Peptides Using Computational Approaches

- Pp. 99-118 (20)
Zeshan Haider, Adnan K. Niazi*
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Molecular Pharming: Research, Developments and Future Perspective

- Pp. 119-161 (43)
Muhammad Sarwar Khan*, Ghulam Mustafa, Faiz Ahmad Joyia
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Green Factories: Plants As A Platform For Costeffective Production of High-value Targets

- Pp. 162-194 (33)
Muhammad Omar Khan, Ayesha Siddiqui, Niaz Ahmad*
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Analysis of Cross-Reactivity, Specificity and the Use of Optimised ELISA for Rapid Detection of Fusarium Spp.

- Pp. 195-225 (31)
Phetole Mangena*, Phumzile Mkhize
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Plant Molecular Pharming For Human Diseases

- Pp. 226-266 (41)
Kiran Saba, Muhammad Suleman Malik, Sara Latif, Fatima Ijaz, Muhammad Sameeullah, Mohammad Tahir Waheed*
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Plant Molecular Farming for Human Therapeutics: Recent Advances and Future Prospects

- Pp. 267-297 (31)
Amna Ramzan, Zainab Y. Sandhu, Saba Altaf, Aisha Tarar, Iqra Arshad, Sumera Rashid, Huma Shakoor, Rabia Abbas, Bushra Rashid*
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Proteins and Peptides as Biomarkers for Diagnosis of Cardiovascular Diseases

- Pp. 298-322 (25)
Sehar Aslam, Samman Munir, Muhammad Shareef Masoud, Usman Ali Ashfaq, Nazia Nahid, Mohsin Khurshid, Muhammad Qasim*
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Veterinary Nutraceutics, Pharmaceutics and Vaccine

- Pp. 323-348 (26)
Amjad Islam Aqib*, Muhammad Shoaib, Muhammad Aamir Naseer, Saad Ahmad, Mubashrah Mahmood, Faisal Siddique, Tean Zaheer, Aisha Mahmood, Iqra Muzammil
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Plant Molecular Pharming For Livestock And Poultry

- Pp. 349-383 (35)
Rimsha Riaz, Saher Qadeer, Faiz Ahmad Joyia, Ghulam Mustafa, Muhammad Sarwar Khan*
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Subject Index

- Pp. 384-390 (7)

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