Editors: Manoj K. Pandey, Vijay P. Kale

Series Title: Recent Advances in Signal Transduction Research and Therapy

Advances in Cancer Signal Transduction and Therapy

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $151
Printed Copy: US $107
Library License: US $356
ISSN: 2737-4424 (Print)
ISSN: 2737-4432 (Online)
ISBN: 978-981-14-5809-5 (Print)
ISBN: 978-981-14-5811-8 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114581181200101

Introduction

Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration. Many of these alterations are often associated with signaling pathways which regulate cell growth and division, cell death, survival, invasion and metastasis, and angiogenesis. Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threonine kinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge about these signaling components is highly desirable for researchers involved in developing therapies against cancer.

Advances in Cancer Signal Transduction and Therapy covers advancements in research on the signaling pathways in the human body, especially in some types of cancers, such as breast cancer, pancreatic cancer and colon cancer.

Key features of this volume include 8 focused topical reviews on signaling pathways in a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (both receptor mediated and non receptor mediated pathways).

This volume is essential reading for researchers in pharmaceutical R&D and postgraduate research programs in pharmacology and allied disciplines. Clinicians involved in oncology will also benefit from the information provided in the chapters.

Contributors

Editor(s):
Manoj K. Pandey
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden, NJ 08103
USA


Vijay P. Kale
Amgen South San Francisco
1120 Veterans Blvd; South San Francisco
CA 94080
USA




Contributor(s):
Alan Prem Kumar
Department of Pharmacology
Yong Loo Lin School of Medicine, National University of Singapore
Singapore


Anup S. Pathania
Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center
University of Nebraska Medical Center
Omaha
USA


Augustus M.C. Tilley
Department of Cancer Biology
University of Toledo Health Science Campus
Toledo
USA


Avtar S. Meena
Department of Pure and Applied Physics
CSIR-Centre for Cellular and Molecular Biology (CCMB) Habsiguda
Hyderabad
India


Bela Peethambaran
Department of Biological Sciences
University of the Sciences
Philadelphia
USA


Cory M. Howard
Department of Cancer Biology
University of Toledo Health Science Campus
Toledo
USA


Dayanidhi Raman
Department of Cancer Biology
University of Toledo Health Science Campus
Toledo
USA


Frank Arfuso
Stem Cell and Cancer Biology Laboratory
School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute
Perth
Australia


Gautam Sethi
Department of Pharmacology
Yong Loo Lin School of Medicine, National University of Singapore
Singapore


Jennifer Dang
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden
USA


Krishne Gowda
Department of Pharmacology
Penn State College of Medicine
Hershey
USA


Kishore B. Challagundla
The Children’s Health Research Institute
University of Nebraska Medical Center
Omaha
USA


Kuntal Bhowmick
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden
USA


Loukik Arora
Department of Pharmacology
Yong Loo Lin School of Medicine. National University of Singapore
Singapore


Manoj K. Pandey
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden
USA


Max Von Suskil
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden
USA


Neelam Yadav
Department of Biochemistry
Rammanohar Lohia Avadh University
Faizabad
India


Norman Fultang
Department of Biological Sciences
University of the Sciences
Philadelphia
USA


Omar S. Al-Odat
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden
USA


Prachi S. Narayan
Department of Biomedical Sciences
Cooper Medical School of Rowan University
Camden
USA


Pradeep K. Shukla
Department of Physiology
University of Tennessee Health Science Center
Memphis
USA


Rachel Weber
Department of Biochemistry and Molecular Biology
University of Nebraska Medical Center
Omaha
USA


Sahdeo Prasad
Department of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy
Texas Tech University Health Sciences Center
Abilene
USA


Sangita Sridharan
Department of Cancer Biology
University of Toledo Health Science Campus
Toledo
USA


Sanjay K. Srivastava
Department of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy
Texas Tech University Health Sciences Center
Abilene
USA


Shantu G Amin
Department of Pharmacology
Penn State College of Medicine
Hershey
USA


Vijay P. Kale
Translational Safety And Bioanalytical Sciences
Amgen Inc.
South San Francisco, CA 94080
USA


Yoganchal Mishra
Department of Biochemistry
Rammanohar Lohia Avadh University
Faizabad
India




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