Editors: Manoj K. Pandey, Vijay P. Kale

Series Title: Recent Advances in Signal Transduction Research and Therapy

Advances in Cancer Signal Transduction and Therapy

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $151
Printed Copy: US $107
Library License: US $356
ISSN: 2737-4424 (Print)
ISSN: 2737-4432 (Online)
ISBN: 978-981-14-5809-5 (Print)
ISBN: 978-981-14-5811-8 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114581181200101


Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration. Many of these alterations are often associated with signaling pathways which regulate cell growth and division, cell death, survival, invasion and metastasis, and angiogenesis. Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threonine kinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge about these signaling components is highly desirable for researchers involved in developing therapies against cancer.

Advances in Cancer Signal Transduction and Therapy covers advancements in research on the signaling pathways in the human body, especially in some types of cancers, such as breast cancer, pancreatic cancer and colon cancer.

Key features of this volume include 8 focused topical reviews on signaling pathways in a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (both receptor mediated and non receptor mediated pathways).

This volume is essential reading for researchers in pharmaceutical R&D and postgraduate research programs in pharmacology and allied disciplines. Clinicians involved in oncology will also benefit from the information provided in the chapters.


- Pp. i-ii (2)
Manoj K. Pandey, Vijay P. Kale
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List of Contributors

- Pp. iii-iv (2)
Manoj K. Pandey, Vijay P. Kale
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Wnt Signaling in Breast Cancer Oncogenesis, Development and Progression

- Pp. 1-28 (28)
Norman Fultang, Bela Peethambaran
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CXCR4 Signaling and its Impact on Tumor Progression and Metastasis in Breast Cancer

- Pp. 29-50 (22)
Dayanidhi Raman, Cory M. Howard, Sangita Sridharan, Augustus M.C. Tilley
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Epidermal Growth Factor Receptor Signaling in Colon Cancer

- Pp. 51-84 (34)
Avtar S. Meena, Pradeep K. Shukla
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Targeting the PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma: Current State and Future Trends

- Pp. 85-98 (14)
Neelam Yadav, Yoganchal Mishra
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MAPK Signaling Pathway: A Central Target in Pancreatic Cancer Therapeutics

- Pp. 99-113 (15)
Sahdeo Prasad, Sanjay K. Srivastava
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Role of NF-κB Activation in Multiple Myeloma and Other Hematological Malignancies

- Pp. 114-130 (17)
Loukik Arora, Frank Arfuso, Alan Prem Kumar, Gautam Sethi
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Bruton’s Tyrosine Kinase Signaling and Advancement in Multiple Myeloma Therapy

- Pp. 131-158 (28)
Krishne Gowda, Max Von Suskil, Omar S. Al-Odat, Jennifer Dang, Kuntal Bhowmick, Prachi S. Narayan, Shantu G Amin
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The Tumor Microenvironment Mediated Signaling Pathways in the Progression of Acute Myeloid Leukemia

- Pp. 159-183 (25)
Anup S. Pathania, Rachel Weber, Kishore B. Challagundla
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Subject Index

- Pp. 184-193 (10)
Manoj K. Pandey, Vijay P. Kale
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.Diabetes and Breast Cancer: An Analysis of Signaling Pathways.