Editor: Touqeer Ahmed

Biochemical Mechanisms of Aluminium Induced Neurological Disorders

eBook: US $59 Special Offer (PDF + Printed Copy): US $100
Printed Copy: US $71
Library License: US $236
ISBN: 978-1-68108-884-6 (Print)
ISBN: 978-1-68108-883-9 (Online)
Year of Publication: 2021
DOI: 10.2174/97816810888391210101


Aluminium is a chemical element present in earth’s crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease.

Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book.

Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

Audience: Students (biochemistry, toxicology and pharmacology), medical specialists (internal medicine and neurology), environmental scientists and general readers


- Pp. i
Touqeer Ahmed*
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List of Contributors

- Pp. ii

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Biochemical Mechanisms of Aluminium and Other Metals Exposure, Their Brain Entry Mechanisms, Effects on Blood Brain Barrier and Important Pharmacokinetic Parameters in Neurological Disorders

- Pp. 1-32 (32)
Sara Ishaq, Amna Liaqat, Armeen Hameed, Touqeer Ahmed*
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Co-Exposure of Aluminium with other Metals Causes Neurotoxicity and Neurodegeneration

- Pp. 33-65 (33)
Abida Zulfiqar, Ghazal Iqbal, Touqeer Ahmed*
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Role of aluminium in Post-Translational Modifications and Neurological Disorders

- Pp. 66-80 (15)
Saadia Zahid*, Sanila Amber, Fatima Javed Mirza
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Effect of Aluminium on Synaptic Plasticity

- Pp. 81-96 (16)
Syeda Mehpara Farhat*
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Aluminium and other Metals Exposure Cause Neurological Disorders: Evidence from Clinical/ human Studies

- Pp. 97-146 (50)
Zehra Batool, Laraib Liaquat, Tuba Sharf Batool, Rida Nisar, Saida Haider*
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Developmental Toxicity of Aluminium and other Metals: Areas Unexplored

- Pp. 147-177 (31)
Laraib Liaquat, Zehra Batool*, Saida Haider
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Subject Index

- Pp. 178-184 (7)

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