Editor: Touqeer Ahmed

Biochemical Mechanisms of Aluminium Induced Neurological Disorders

eBook: US $59 Special Offer (PDF + Printed Copy): US $108
Printed Copy: US $78
Library License: US $236
ISBN: 978-1-68108-884-6 (Print)
ISBN: 978-1-68108-883-9 (Online)
Year of Publication: 2021
DOI: 10.2174/97816810888391210101

Introduction

Aluminium is a chemical element present in earth’s crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease.

Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book.

Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

Audience: Students (biochemistry, toxicology and pharmacology), medical specialists (internal medicine and neurology), environmental scientists and general readers

Preface

This book “Biochemical Mechanisms of Aluminium Induced Neurological Disorders” is composed of six chapters contributed by reputed scientists working in the field of metals neurotoxicity and studying the role of metals on various neurological disorders. The salient features of this book which make it unique are– it highlights the basic as well as clinical mechanisms of metals induced neurotoxicity in various neurological disorders, and another unique feature of this book is that it discusses the role of Aluminium induced neurological disorders, alone and in combination with other toxic metals as well as with the high fat diet intake, thus adding diversity and unraveling new features of metals neurotoxicity in real scenarios.

Aluminium is present in the earth’s crust and it is a well known environmental toxin/metal which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease. It is known to cause neurotoxicity by various mechanisms, which are highlighted in this book. Cholinergic system impairment seems to be prominent; however, other mechanisms and pathways are also discussed and elaborated in this book. This book also covers missing aspects of the blood brain barrier and developmental toxicity, which are not very well studied areas related to Aluminium exposure alone or in combination with other metals. Knowing the pharmacokinetics of Aluminium and other metals are important aspects that can help us to understand the exposure of metals and their brain entry mechanisms, thus, opening up new horizons for the development of therapeutic options. Finally, I would say that this comprehensive book is well balanced and well written in developing understandings of basic and clinical mechanisms of Aluminium induced neurological disorders.

Touqeer Ahmed
Department of Healthcare Biotechnology
Atta-ur-Rahman School of Applied Biosciences
National University of Sciences and Technology
Islamabad, Pakistan