Editors: M.O. Faruk Khan, Ashok Philip

Series Title: Medicinal Chemistry for Pharmacy Students

Fundamentals of Medicinal Chemistry and Drug Metabolism

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISSN: 2589-6997 (Print)
ISSN: 2589-6989 (Online)
ISBN: 978-1-68108-688-0 (Print)
ISBN: 978-1-68108-687-3 (Online)
Year of Publication: 2018
DOI: 10.2174/97816810868731180101

Introduction

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic background information about medicinal chemistry. It takes a succinct and conceptual approach to introducing important fundamental concepts required for a clear understanding of various facets of pharmacotherapeutic agents, drug metabolism and important biosynthetic pathways that are relevant to drug action. Notable topics covered in this first volume include the scope and importance of medicinal chemistry in pharmacy education, a comprehensive discussion of the organic functional groups present in drugs, and information about four major types of biomolecules (proteins, carbohydrates, lipids, nucleic acids) and key heterocyclic ring systems. The concepts of acid-base chemistry and salt formation, and their applications to the drug action and design follow thereafter. These include concepts of solubility and lipid-water partition coefficient (LWPC), isosterism, stereochemical properties, mechanisms of drug action, drug receptor interactions critical for pharmacological responses of drugs, and much more. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body.

Contributors

Editor(s):
M.O. Faruk Khan
Marshall University School of Pharmacy
Huntington, WV
USA


Ashok Philip
Union University College of Pharmacy
Jackson, TN
USA




Contributor(s):
M. O. Faruk Khan
Department of Pharmaceutical Sciences and Research
Marshall University School of Pharmacy, Huntington, WV
USA


Ashok Philip
Department of Pharmaceutical Sciences, Union University School of Pharmacy
Jackson, TN
USA


Ashim Malhotra
Department of Pharmaceutical and Biomedical Sciences
College of Pharmacy, California Northstate University
Elk Grove, CA
USA


Hardeep Singh Saluja
Department of Pharmaceutical Sciences
Southwestern Oklahoma State University College of Pharmacy
Weatherford, Oklahoma
USA


Timothy J. Hubin
Department of Chemistry
Southwestern Oklahoma State University
Weatherford, Oklahoma
USA


Taufiq Rahman
Department of Pharmacology
University of Cambridge
Cambridge
UK


Rahmat Talukder
Department of Pharmaceutical Sciences
University of Texas at Tyler College of Pharmacy
Tyler, TX
USA


Jason L. Johnson
Department of Chemistry and Physics
Southwestern Oklahoma State University
Weatherford, Oklahoma
USA




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