Editors: Marcelo Santos da Silva, Maria Isabel N. Cano

Series Title: Frontiers in Parasitology

Molecular and Cellular Biology of Pathogenic Trypanosomatids

Volume 1

eBook: US $99 Special Offer (PDF + Printed Copy): US $245
Printed Copy: US $195
Library License: US $396
ISSN: 2542-4211 (Print)
ISSN: 2542-422X (Online)
ISBN: 978-1-68108-406-0 (Print)
ISBN: 978-1-68108-405-3 (Online)
Year of Publication: 2017
DOI: 10.2174/97816810840531170101

Introduction

Every year millions of people living in tropical areas across the globe, are affected by trypanosomatids – the parasites causing Chagas disease, African trypanosomiasis, and leishmaniasis. According to WHO, these diseases are termed as neglected tropical diseases against which there are no effective vaccines and the few available treatments have many side effects, besides posing the risk of emerging drug resistant parasite strains. All these factors represent a significant challenge which imposes a considerable economic burden to public health systems. Many research initiatives have emerged in recent years with the aim to undercover parasitic molecular and cellular biology, parasite-host interactions, mechanisms of disease pathogenesis, molecular mechanisms of drug resistance, all essential for the development of novel anti-parasite treatments and eradication strategies.

This volume highlights discoveries in the field of trypanosomatid molecular and cellular biology. Topics covered include cell organization during development, genome organization and maintenance, control of gene expression, nuclear and kinetoplast DNA replication, mechanisms of DNA damage repair, virulence factors and immune evasion, new methods for molecular diagnosis, new therapeutic tools and recombinant vaccine biology.

This monograph will be of interest to undergraduates (premedical and biologists), graduates (masters and Ph.D. students) the parasitology research community and researchers working in related fields.

Contributors

Editor(s):
Marcelo Santos da Silva
Instituto Butantan
São Paulo
Brazil


Maria Isabel N. Cano
Universidade Estadual Paulista, “Júlio de Mesquita Filho” (UNESP)
São Paulo
Brazil




Contributor(s):
Alba Marina Gimenez
Universidade Federal de São Paulo, São Paulo
Brazil


Alejandro G. Schijman
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Ciudad de Buenos Aires
Argentina


Bessy Gutiérrez
University of Antofagasta, Antofagasta
Chile


Bruna M. Valente
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Camila B. Storti
Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Botucatu, São Paulo
Brazil


Carlos R. Machado
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Christiane Araújo
Instituto Butantan, São Paulo
Brazil


Cristiane Regina Antonio
Universidade Federal de São Paulo, São Paulo
Brazil


Daniella Castanheira Bartholomeu
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Edna Gicela Ortiz Morea
Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Botucatu, São Paulo
Brazil


Gonzalo Cabrera
Universidad de Chile, Santiago
Chile


Hugo Oswaldo Valdivia
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Isabela C. Mendes
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Jair L. Siqueira-Neto
University of California San Diego, La Jolla
USA


João Luís Reis-Cunha
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Jorge Araya
University of Antofagasta, Antofagasta
Chile


Jorge González
University of Antofagasta, Antofagasta
Chile


José Franco da Silveira
Universidade Federal de São Paulo, São Paulo
Brazil


José L. Vega
University of Antofagasta, Antofagasta
Chile


Jose M. Requena
Universidad Autónoma de Madrid, Madrid
Spain


Juan M. Burgos
Universidad Nacional de San Martín, Provincia de Buenos Aires
Argentina


Julia Pinheiro C. da Cunha
Instituto Butantan, São Paulo
Brazil


Leonardo da Silva Augusto
Universidade Federal de São Paulo, São Paulo
Brazil


Loyze P. Oliveira de Lima
Instituto Butantan, São Paulo
Brazil


Manuel Soto
Universidad Autónoma de Madrid, Madrid
Spain


Marcelo Santos da Silva
Instituto Butantan, São Paulo
Brazil


Maria Alejandra Viviescas
Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Botucatu, São Paulo
Brazil


Maria Carolina Elias
Instituto Butantan, São Paulo
Brazil


Maria Isabel Nogueira Cano
Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Botucatu, São Paulo
Brazil


Mariana de Camargo Lopes
Instituto Butantan, São Paulo
Brazil


Marjorie Mendes Marini
Universidade Federal de São Paulo, São Paulo
Brazil


Maurício Martins Rodrigues
Universidade Federal de São Paulo, São Paulo
Brazil


Miguel Angel Chiurillo
Universidade de Campinas, Campinas
Brazil


Nilmar Silvio Moretti
Universidade Federal de São Paulo, São Paulo
Brazil


Paula L. Marcet
Center for Diseases, Control and Prevention (CDC), Atlanta
United States of America


Priscila Martins Andrade Denapoli
Universidade Federal de São Paulo
Brazil


Raphael Souza Pavani
Instituto Butantan, São Paulo
Brazil


Renata Torres de Souza
Universidade Federal de São Paulo, São Paulo
Brazil


Richard McCulloch
University of Glasgow, Glasgow
UK


Santuza M. R. Teixeira
Universidade Federal de Minas Gerais, Minas Gerais
Brazil


Sergio Schenkman
Universidade Federal de São Paulo, São Paulo
Brazil


Simone Guedes Calderano
Instituto Butantan, São Paulo
Brazil


Teresa Cristina Leandro
Teresa Cristina Leandro de Jesus Instituto Butantan, São Paulo
Brazil


Viviane G. Silva
Universidade Federal de Minas Gerais, Minas Gerais
Brazil




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