Editors: Marcelo Santos da Silva, Maria Isabel N. Cano

Series Title: Frontiers in Parasitology

Molecular and Cellular Biology of Pathogenic Trypanosomatids

Volume 1

eBook: US $99 Special Offer (PDF + Printed Copy): US $245
Printed Copy: US $195
Library License: US $396
ISSN: 2542-4211 (Print)
ISSN: 2542-422X (Online)
ISBN: 978-1-68108-406-0 (Print)
ISBN: 978-1-68108-405-3 (Online)
Year of Publication: 2017
DOI: 10.2174/97816810840531170101

Introduction

Every year millions of people living in tropical areas across the globe, are affected by trypanosomatids – the parasites causing Chagas disease, African trypanosomiasis, and leishmaniasis. According to WHO, these diseases are termed as neglected tropical diseases against which there are no effective vaccines and the few available treatments have many side effects, besides posing the risk of emerging drug resistant parasite strains. All these factors represent a significant challenge which imposes a considerable economic burden to public health systems. Many research initiatives have emerged in recent years with the aim to undercover parasitic molecular and cellular biology, parasite-host interactions, mechanisms of disease pathogenesis, molecular mechanisms of drug resistance, all essential for the development of novel anti-parasite treatments and eradication strategies.

This volume highlights discoveries in the field of trypanosomatid molecular and cellular biology. Topics covered include cell organization during development, genome organization and maintenance, control of gene expression, nuclear and kinetoplast DNA replication, mechanisms of DNA damage repair, virulence factors and immune evasion, new methods for molecular diagnosis, new therapeutic tools and recombinant vaccine biology.

This monograph will be of interest to undergraduates (premedical and biologists), graduates (masters and Ph.D. students) the parasitology research community and researchers working in related fields.

Foreword

- Pp. i-iii (3)
Walter Colli
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Preface

- Pp. iv-v (2)
Marcelo Santos da Silva and Maria Isabel N. Cano
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List of Contributors

- Pp. vi-vii (2)
Marcelo Santos da Silva and Maria Isabel N. Cano
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The Cellular Organization of Trypanosomatids During Life Cycle

- Pp. 3-60 (58)
Simone Guedes Calderano, Nilmar Silvio Moretti, Christiane Araujo, Marcelo S. da Silva, Teresa Cristina Leandro de Jesus, Loyze P. Oliveira de Lima, Mariana de Camargo Lopes, Leonardo da Silva Augusto, Julia Pinheiro Chagas da Cunha, Maria Carolina Elias and Sergio Schenkman

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Trypanosomatid Genome Organization and Ploidy

- Pp. 61-103 (43)
João Luís Reis-Cunha, Hugo Oswaldo Valdivia and Daniella Castanheira Bartholomeu

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Chromosomes Ends and Telomere Biology of Trypanosomatids

- Pp. 104-133 (30)
Miguel Angel Chiurillo, Cristiane Regina Antonio, Marjorie Mendes Marini, Renata Torres de Souza and José Franco da Silveira

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Nuclear and Kinetoplast DNA Replication in Trypanosomatids

- Pp. 134-194 (61)
Marcelo S. da Silva, Maria Alejandra Viviescas, Raphael Souza Pavani, Edna Gicela Ortiz, Camila B. Storti and Maria Isabel N. Cano

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Genome Maintenance in Trypanosomatids

- Pp. 195-260 (66)
Gonzalo Cabrera, Viviane G. Silva, Isabela C. Mendes, Carlos R. Machado and Richard McCulloch
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Mechanisms Controlling Gene Expression in Trypanosomatids

- Pp. 261-290 (30)
Santuza M. R. Teixeira and Bruna M. Valente

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Virulence Factors and Immune Evasion in Leishmania spp.

- Pp. 291-345 (55)
Jose M. Requena and Manuel Soto

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Virulence Factors and Immune Evasion in Trypanosoma cruzi

- Pp. 346-393 (48)
Jorge González, Bessy Gutiérrez, José L. Vega and Jorge E. Araya

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Molecular Tools and Strategies for Diagnosis of Chagas Disease and Leishmaniasis

- Pp. 394-453 (60)
Alejandro G. Schijman, Juan M. Burgos and Paula L. Marcet

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New Chemotherapy Against Trypanosomiasis and Leishmaniasis

- Pp. 454-530 (77)
Jair L. de Siqueira-Neto

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Recombinant Vaccines Against Pathogenic Trypanosomatids

- Pp. 531-585 (55)
Priscila Martins Andrade Denapoli, Alba Marina Gimenez and Maurício Martins Rodrigues

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Subject Index

- Pp. 586-595 (10)
Marcelo Santos da Silva and Maria Isabel N. Cano
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