Editor: Qun Zhou

Series Title: Recent Advances in Biotechnology

Recent Progress in Glycotherapy

Volume 3

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISSN: 2468-5364 (Print)
ISSN: 2468-5372 (Online)
ISBN: 978-1-68108-392-6 (Print)
ISBN: 978-1-68108-391-9 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810839261160301

Introduction

Carbohydrates (monosaccharides, oligosaccharides and polysaccharides) exist naturally in free from and as components of other macromolecules (nucleic acids, proteins and lipids). Glycotherapy refers to this use of carbohydrates or glycoengineered macromolecules in fighting life-threatening diseases. Although glycotherapy is a relatively new and limited field of pharmacology, significant progress has been made in recent years in academia and the pharmaceutical industry facilitated by advances in enzymology and recombinant DNA technologies. Consequently, carbohydrate containing biologics are now used in therapeutic regimens.

This volume provides a summary of the progress made in developing therapeutic solutions using glycoengineering techniques. Topics covered in this volume include the development of vaccines and antibodies against tumor-associated carbohydrate antigens for cancer treatment, the use of glycan for viral inhibition, glycoPEGylation, hyaluronic acid conjugation, and protein modification and conjugation for increasing therapeutic index using recombinant and chemoenzymatic approaches. The volume is essential reading for biochemists, pharmacologists and R&D professionals interested in glycotherapy.

Contributors

Editor(s):
Qun Zhou
Protein Engineering
Global BioTherapeutics, Sanofi, Framingham
Massachusetts 01701
United States




Contributor(s):
Anna Mero
Department of Pharmaceutical and Pharmacological Sciences
University of Padova, Via F. Marzolo 5
35131 Padua
Italy


Antonella Grigoletto
Department of Pharmaceutical and Pharmacological Sciences
University of Padova, Via F. Marzolo 5
35131 Padua
Italy


Che C. Colpitts
Inserm, U1110
Institut de Recherche sur les Maladies Virales et Hépatiques
67000 Strasbourg
France.
/
Université de Strasbourg
67000 Strasbourg
France


Diana P. Sousa
UCIBIO, Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
Portugal.


Gabriele Martinez
Veneto Institute of Oncology IOV-IRCCS
Padova
Italy


Gianfranco Pasut
Department of Pharmaceutical and Pharmacological Sciences
University of Padova, Via F. Marzolo 5
35131 Padua
Italy.
/
Veneto Institute of Oncology IOV-IRCCS
Padova
Italy


Huawei Qiu
Protein Engineering
Sanofi, 5 Mountain Road
Framingham, MA 01701
United States


Huijuan Li
Sterile Product and Analytical Development
Biologics and Vaccine Development, Merck & Co., Inc.
Kenilworth
NJ USA


Kevin B. Turner
Sterile Product and Analytical Development
Biologics and Vaccine Development, Merck & Co., Inc.
Kenilworth
NJ USA


Liliana R. Loureiro
UCIBIO, Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
Portugal.


Marcos Oggero
UNL, CONICET, Cell Culture Laboratory
FBCB. Edificio FBCB-Ciudad Universitaria UNL. C.C. 242. (S3000ZAA) Santa Fe.
Argentina


Marina Etcheverrigaray
UNL, CONICET, Cell Culture Laboratory
FBCB. Edificio FBCB-Ciudad Universitaria UNL. C.C. 242. (S3000ZAA) Santa Fe.
Argentina


M. Eugenia Giorgi
CIHIDECAR-CONICET, Departamento de Química Orgánica
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires
Buenos Aires
Argentina


Mylène A. Carrascal
UCIBIO, Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
Portugal.


Natalia Ceaglio
UNL, CONICET, Cell Culture Laboratory
FBCB. Edificio FBCB-Ciudad Universitaria UNL. C.C. 242. (S3000ZAA) Santa Fe.
Argentina


Paula A. Videira
UCIBIO, Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
Portugal.
/
Univ. Lille, Inserm
U908 - CPAC - Cell Plasticity and Cancer
F-59000 Lille
France


Philippe Delannoy
Univ. Lille, CNRS
UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille
France


Qun Zhou
Protein Engineering
Sanofi, 5 Mountain Road
Framingham, MA 01701
United States


Ricardo Kratje
UNL, CONICET, Cell Culture Laboratory
FBCB. Edificio FBCB-Ciudad Universitaria UNL. C.C. 242. (S3000ZAA) Santa Fe.
Argentina


Robert Yite Chou
Sterile Product and Analytical Development
Biologics and Vaccine Development, Merck & Co., Inc.
Kenilworth
NJ USA


Rosa M. de Lederkremer
CIHIDECAR-CONICET, Departamento de Química Orgánica
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires
Buenos Aires
Argentina


Rosalia Agusti
CIHIDECAR-CONICET, Departamento de Química Orgánica
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires
Buenos Aires
Argentina


Sylvain Julien
Univ. Lille, Inserm
U908 - CPAC - Cell Plasticity and Cancer
F-59000 Lille
France


Thomas F. Baumert
Inserm, U1110
Institut de Recherche sur les Maladies Virales et Hépatiques
67000 Strasbourg
France.
/
Université de Strasbourg
67000 Strasbourg
France.
/
Institut Hospitalo-Universitaire
Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg
67000 Strasbourg
France




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