Editor: Qun Zhou

Series Title: Recent Advances in Biotechnology

Recent Progress in Glycotherapy

Volume 3

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISSN: 2468-5364 (Print)
ISSN: 2468-5372 (Online)
ISBN: 978-1-68108-392-6 (Print)
ISBN: 978-1-68108-391-9 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810839261160301

Introduction

Carbohydrates (monosaccharides, oligosaccharides and polysaccharides) exist naturally in free from and as components of other macromolecules (nucleic acids, proteins and lipids). Glycotherapy refers to this use of carbohydrates or glycoengineered macromolecules in fighting life-threatening diseases. Although glycotherapy is a relatively new and limited field of pharmacology, significant progress has been made in recent years in academia and the pharmaceutical industry facilitated by advances in enzymology and recombinant DNA technologies. Consequently, carbohydrate containing biologics are now used in therapeutic regimens.

This volume provides a summary of the progress made in developing therapeutic solutions using glycoengineering techniques. Topics covered in this volume include the development of vaccines and antibodies against tumor-associated carbohydrate antigens for cancer treatment, the use of glycan for viral inhibition, glycoPEGylation, hyaluronic acid conjugation, and protein modification and conjugation for increasing therapeutic index using recombinant and chemoenzymatic approaches. The volume is essential reading for biochemists, pharmacologists and R&D professionals interested in glycotherapy.

Foreword

- Pp. i
David F. Smith
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Preface

- Pp. ii-iii (2)
Qun Zhou
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List of Contributors

- Pp. iv-v (2)
Qun Zhou
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Vaccine and Antibody Therapy Against Thomsen- Friedenreich Tumor-Associated Carbohydrate Antigens

- Pp. 3-38 (36)
Paula A. Videira, Sylvain Julien, Liliana R. Loureiro, Diana P. Sousa, Mylène A. Carrascal and Philippe Delannoy
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Cell Surface Glycans as Viral Entry Factors and Targets for Broadly Acting Antivirals

- Pp. 39-59 (21)
Che C. Colpitts and Thomas F. Baumert

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Carbohydrate PEGylation in Chemotherapy

- Pp. 60-101 (42)
Rosalia Agusti, M. Eugenia Giorgi and Rosa M. de Lederkremer

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Recent Developments in Hyaluronic Acid-Based Nanomedicine

- Pp. 102-129 (28)
Anna Mero, Antonella Grigoletto, Gabriele Martinez and Gianfranco Pasut

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Utilization of Glycosylation Engineering in the Development of Therapeutic Proteins

- Pp. 130-151 (22)
Robert Yite Chou, Kevin B. Turner and Huijuan Li

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Antibody Engineering through Fc Glycans for Improved Therapeutic Index

- Pp. 152-171 (20)
Qun Zhou and Huawei Qiu

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Engineering of Therapeutic Proteins through Hyperglycosylation

- Pp. 172-208 (37)
Natalia Ceaglio, Marina Etcheverrigaray, Ricardo Kratje and Marcos Oggero

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Subject Index

- Pp. 209-217 (9)
Qun Zhou

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