Editor: "David J. Hill"

Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes

Volume 1

Personal Book: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library Book: US $356
ISSN: 2468-7537
eISSN: 2468-7545 (Online)
ISBN: 978-1-68108-366-7
eISBN: 978-1-68108-365-0 (Online)
DOI: 10.2174/97816810836501160101

Introduction

Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity:

-current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan

-the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators

-the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors

This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.

Contributors

Editor(s):
David J. Hill
Lawson Health Research Institute
St. Joseph’s Health Care, 268 Grosvenor Street
London, Ontario N6A 4V2
Canada




Contributor(s):
Aaron R. Cox
McNair Medical Institute
Baylor College of Medicine
Houston
Texas


Amarnadh Nalla
Department of Biomedical Sciences
University of Copenhagen
Denmark
/
Centre for Fetal Programming
Copenhage
Denmark


Ananta Poudel
Department of Medicine
The University of Chicago
Chicago
USA


Angela Herengt Darmon
INSERM, U1016
Institut Cochin
Paris
France
/
Université Paris Descartes
Sorbonne Paris Cité, Faculté de Médecine
Paris
France


Benjamin Broche
INSERM, U1016
Institut Cochin
Paris
France
/
Université Paris Descartes
Sorbonne Paris Cité, Faculté de Médecine
Paris
France


Bertrand Duvillié
INSERM, U1016
Institut Cochin
Paris
France
/
Université Paris Descartes
Sorbonne Paris Cité, Faculté de Médecine
Paris
France


Birgitte Søstrup
Department of Biomedical Sciences
University of Copenhagen
Denmark
/
Centre for Fetal Programming
Copenhage
Denmark


Brian T. Layden
Division of Endocrinology, Metabolism and Molecular Medicine
Northwestern University Feinberg School of Medicine
Chicago, Illinois
USA
/
Jesse Brown Veterans Affairs Medical Center
Chicago, Illinois
USA


Christine A. Beamish
Department of Surgery, Islet Transplantation Laboratory
The Methodist Hospital Research Institute
Houston Texas
USA


David A. Hess
Molecular Medicine Research Group, Krembil Centre for Stem Cell Biology, Robarts Research Institute; Department of Physiology & Pharmacology
Schulich School of Medicine & Dentistry, Western University, London
Ontario
Canada


David J Hill
Lawson Health Research Institute
St. Joseph’s Health Care, 268 Grosvenor Street, London
Ontario N6A 4V2
Canada


Jeanette Kirkegaard
Department of Biomedical Sciences
University of Copenhagen
Denmark
/
Novo Nordisk A/S
Måløv
Denmark


Jens Høiriis Nielsen
Department of Biomedical Sciences
University of Copenhagen
Denmark
/
Centre for Fetal Programming
Copenhage
Denmark


Jonas Fowler
Department of Medicine
The University of Chicago
Chicago
USA


Manami Hara
Department of Medicine
The University of Chicago
Chicago
USA


Mulchand S. Patel
Department of Biochemistry
School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo
New York 14214
USA


Paul Richards
INSERM, U1016
Institut Cochin
Paris
France
/
Université Paris Descartes
Sorbonne Paris Cité, Faculté de Médecine
Paris
France


Ruth M. Elgamal
Molecular Medicine Research Group, Krembil Centre for Stem Cell Biology, Robarts Research Institute; Department of Physiology & Pharmacology
Schulich School of Medicine & Dentistry, Western University, London
Ontario
Canada


Saleh Mahmood
Department of Biochemistry
School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo
New York 14214
USA


Signe Horn
Department of Biomedical Sciences
University of Copenhagen
Denmark
/
Novo Nordisk A/S
Måløv
Denmark


Stephanie Villa
Division of Endocrinology, Metabolism and Molecular Medicine
Northwestern University Feinberg School of Medicine
Chicago, Illinois
USA


Tyler T. Cooper
Molecular Medicine Research Group, Krembil Centre for Stem Cell Biology, Robarts Research Institute; Department of Physiology & Pharmacology
Schulich School of Medicine & Dentistry, Western University, London
Ontario
Canada


William L. Lowe
Division of Endocrinology, Metabolism and Molecular Medicine
Northwestern University Feinberg School of Medicine
Chicago, Illinois
USA




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