Editor: Takanori Kawaguchi

Cancer Metastasis and Cancer Stem Cell/Niche

eBook: US $49 Special Offer (PDF + Printed Copy): US $113
Printed Copy: US $89
Library License: US $196
ISBN: 978-1-68108-348-3 (Print)
ISBN: 978-1-68108-347-6 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810834761160101


A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches.

Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells in the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis.

This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.

Indexed in: Book Citation Index, Science; BIOSIS Previews, EBSCO.


- Pp. i-ii (2)
Julio Aguirre-Ghiso
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- Pp. iii
Takanori Kawaguchi
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- Pp. iv
Takanori Kawaguchi
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List of Contributors

- Pp. v-vi (2)
Takanori Kawaguchi
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Fundamental Relationships Between Cancer Stem Cells, the Cancer Stem Cell Niche and Metastasis

- Pp. 3-23 (21)
Eric D. Young, Linheng Li, Fariba Behbod, Danny R. Welch
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Regulation of Cell Surface Glycan Expression in Cancer Stem Cells

- Pp. 24-60 (37)
Reiji Kannagi, Bi-He Cai, Hsiang-Chi Huang, Keiichiro Sakuma
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Tumor Endothelial Cells and Cancer Progression

- Pp. 61-73 (13)
Kyoko Hida, Nako Maishi, Dorcas A. Annan, Yasuhiro Hida
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Metastatic Cancer Stem Cell Niche and the Tolllike Receptor 4 (TLR4)-mediated Premetastatic Microenvironment

- Pp. 74-108 (35)
Takeshi Tomita, Atsuko Deguchi, Yoshiro Maru
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Cancer Stem Cell and Clinical Cancer Metastasis in Surgical Oncology

- Pp. 109-133 (25)
Shoji Nakamori, Koji Morimoto
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Subject Index

- Pp. 134-145 (12)
Takanori Kawaguchi
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