Editors: "Monica Neagu", "Cristiana Tanase"

Stem Cells between Regeneration and Tumorigenesis

eBook: US $39 Special Offer (PDF + Printed Copy): US $174
Printed Copy: US $155
Library License: US $156
ISBN: 978-1-68108-332-2 (Print)
ISBN: 978-1-68108-331-5 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810833151160101

Introduction

Experts in the field of cellular biology have shown that the reactivation of pluripotency inherent in all cells can allow us to reprogram cells into a specific cell line. This reprogramming paradigm is steadily enhancing our understanding of cell differentiation processes and cellular identity. Consequently, new prospects for cellular therapies of diseases and in vivo regeneration have risen.

Stem Cells Between Regeneration and Tumorigenesis focuses on organ specific molecular pathways that trigger two opposite ways that a stem cell can grow (regeneration and neoplasia). Chapters provide a balanced set of information about tissue regeneration and tumorigenesis in several tissues and biological systems (the nervous, circulatory, oral, skin, digestive and endocrine systems). Additional reviews of the immunological role in regulating the two stem cell growth processes and the role of genomics and proteomics in understanding these processes round up the contents of this monograph.

Readers of this book will gain the following key benefits:

-an insight into the complexity and controversy surrounding the established dual stem cell behavior paradigm (regeneration versus tumorigenesis)

-an understanding of the intricate cellular processes such as stem cells maintenance

-background knowledge of optimizing tailored therapy in personalized and regenerative medicine

Stem Cells Between Regeneration and Tumorigenesis is a useful resource for advanced graduates and researchers undertaking courses in molecular biology and personalized medicine, as well as interns involved in stem cell research programs.

Reviews

Review 1

Stem cell populations are well-defined and experimentally tractable, but most importantly, they share many properties with cancer stem cells. For that reason, their proliferation patterns are studied both in regeneration as well as in tumorigenesis.

Stem Cells Between Regeneration and Tumorigenesis presents the latest updates linked to the triggers of the two opposite ways a stem cell can follow. It explores different approaches such as signal transduction, stem cell markers, immune-related processes, “omics” technologies, and pharmacological trends in order to highlight stem cell proliferation patterns. This means that reader will gain a better understanding of hematopoietic stem cell biology, skin stem cells in regeneration and tumorigenesis, cancer stem cells in oral pathology and stem cells’ involvement in neurological and endocrine pathology. It offers an insight into the crucial role of the stem cell niche, especially its microenvironment responsible for different molecular interactions between the niche and normal and malignant stem cells.

The reader will learn about the latest advancements in hematopoietic stem cells, stem cells that are involved in neurodegeneration and brain tumors and in endocrine pathology, how the immune system controls stem cells, and the proteomics behind these cells and the latest technologies involved in stem cells identification. It also includes details of micro- and nano-technologies designed to monitor stem cell differentiation.

The title deserves its place amongst its competing titles, since it provides a clearer understanding of the difference between “normal” stem cells involved in regeneration, and how they are disrupted leading to cancer stem cells and the formation of tumors.


Sanda Maria Cretoiu, MD, PhD
Associate Professor,
Department of Cellular and Molecular Medicine,
'Carol Davila' University of Medicine and Pharmacy,
8 Eroii Sanitari Blvd., Bucharest 050474, Romania.


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