Editors: Monica Neagu, Cristiana Tanase

Stem Cells between Regeneration and Tumorigenesis

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISBN: 978-1-68108-332-2 (Print)
ISBN: 978-1-68108-331-5 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810833151160101

Introduction

Experts in the field of cellular biology have shown that the reactivation of pluripotency inherent in all cells can allow us to reprogram cells into a specific cell line. This reprogramming paradigm is steadily enhancing our understanding of cell differentiation processes and cellular identity. Consequently, new prospects for cellular therapies of diseases and in vivo regeneration have risen.

Stem Cells Between Regeneration and Tumorigenesis focuses on organ specific molecular pathways that trigger two opposite ways that a stem cell can grow (regeneration and neoplasia). Chapters provide a balanced set of information about tissue regeneration and tumorigenesis in several tissues and biological systems (the nervous, circulatory, oral, skin, digestive and endocrine systems). Additional reviews of the immunological role in regulating the two stem cell growth processes and the role of genomics and proteomics in understanding these processes round up the contents of this monograph.

Readers of this book will gain the following key benefits:

-an insight into the complexity and controversy surrounding the established dual stem cell behavior paradigm (regeneration versus tumorigenesis)

-an understanding of the intricate cellular processes such as stem cells maintenance

-background knowledge of optimizing tailored therapy in personalized and regenerative medicine

Stem Cells Between Regeneration and Tumorigenesis is a useful resource for advanced graduates and researchers undertaking courses in molecular biology and personalized medicine, as well as interns involved in stem cell research programs.

Foreword

- Pp. i-ii (2)
Giovanni Pellacani
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Preface

- Pp. iii-v (3)
Monica Neagu and Cristiana Tanase
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List of Contributors

- Pp. vi-viii (3)
Monica Neagu and Cristiana Tanase
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Stem Cells in Hematopoietic Processes and Therapy Tools

- Pp. 3-36 (34)
Siqi Chen, Qiang Huang, Qing Li, Yawei Liu and Zhong Wang

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Epithelial Oral Stem Cells

- Pp. 37-62 (26)
Pieter J. Slootweg and Sabina Zurac

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Skin Stem Cells in Cutaneous Wound Healing and Tumorigenesis

- Pp. 63-105 (43)
Constantin Caruntu, Daniel Boda, Ana Caruntu and Caterina Longo

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Stem Cells in Neurodegeneration

- Pp. 106-132 (27)
Ana-Maria Enciu

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Cancer Stem Cells in Brain Tumorigenesis

- Pp. 133-171 (39)
Maria Linda Cruceru and Adrian Claudiu Popa

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Adult Pituitary Stem Cells

- Pp. 172-186 (15)
Ancuta Augustina Gheorghisan-Galateanu

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Cancer Stem Cells in Pancreatic and Hepatocellular Carcinoma: Similarities and Differences

- Pp. 187-201 (15)
Simona Olimpia Dima, Dana Cucu, Nicolae Bacalbasa, Valeria Tica and Irinel Popescu

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Immunogenicity of Stem Cell in Tumorigenesis Versus Regeneration

- Pp. 202-234 (33)
Monica Neagu and Carolina Constantin

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Current Proteomic Studies for New Concept in Stem Cell Biology

- Pp. 235-280 (46)
Cristiana Pistol Tanase, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Laura Necula and Radu Albulescu

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Nano and Microtechnology for Monitoring Stem Cell Differentiation

- Pp. 281-320 (40)
Larisa-Emilia Cheran, Alin Cheran, Andreea-Roxana Lupu and Traian Popescu

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Subject Index

- Pp. 321-322 (2)
Monica Neagu and Cristiana Tanase
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