Editors: Kazuyuki Shimizu, Yu Matsuoka

Fundamentals of Systems Analysis and Modeling of Biosystems and Metabolism

eBook: US $99 Special Offer (PDF + Printed Copy): US $168
Printed Copy: US $119
Library License: US $396
ISBN: 978-1-68108-087-1 (Print)
ISBN: 978-1-68108-086-4 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810808641150101


An understanding of biological systems at cellular and molecular levels helps researchers to model cellular behavior in different experimental conditions. This, in turn, can lead to insights about the influence of cell culture environment and the effect of knockout gene research when studying mutations that affect specific metabolic pathways. A systems biology approach, therefore, allows researchers to simulate experimental observations in order to predict outcomes at the cellular level.

Fundamentals of Systems Analysis and Modeling of Biosystems and Metabolism presents the basic concepts required for a systems biology approach towards cellular modeling. The book is intended as a primer for systems biology and biomedical engineering graduates and researchers. The text introduces readers to concepts related to cellular metabolism and its regulation, (enzymatic regulation and transcriptional regulation) which are also incorporated into a main metabolic model of a cell. The book also has chapters dedicated to identifying and incorporating steady-state and dynamic characteristics when considering a biological model for a computer simulation.

Readers will be able to (1) understand the basis of systems analysis towards creating appropriate biological models and simulations, (2) develop useful kinetic models based on cellular transport phenomena and metabolic regulation, (3) understand how to simulate a cell growth phenotype, and analyze it with experimental data.


I am honored to be able to contribute to this exciting eBook about microbial systems biology, modeling, and metabolic regulation of the main metabolism of a cell. The eBook has excellent credentials for describing important knowledge and approaches for the understanding of metabolic regulation of a cell system in general, since the main metabolism is common and conserved in a variety of living organisms.

Professor Kazuyuki Shimizu and I have been the project leaders of UK-Japan microbial systems biology research for long time. He has been involved in 13C-metabolic flux analysis and systems biology to clarify the metabolic regulation of Esherichia coli. He has published many articles in this area.

In summary, I am delighted to see such expertly produced and well referenced eBook which will contribute for both biochemical science and metabolic engineering as well as bioinformatics.

Johnjoe Mcfadden
Associate Dean (International)
Faculty of Health and Medical Sciences
University of Surrey
Guildford, Surrey