Author: Robert E. Smith

Medicinal Chemistry - Fusion of Traditional and Western Medicine, Third Edition

eBook: US $99 Special Offer (PDF + Printed Copy): US $259
Printed Copy: US $210
Library License: US $396
ISBN: 978-1-68108-079-6 (Print)
ISBN: 978-1-68108-078-9 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810807891150301


Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking.

The 3rd edition attempts to explain the predictive, preventive, personalized and participatory (P4) paradigm of medicinal chemistry. This edition features new chapters focusing on personalized medicinal chemistry and the endocrine system (with a discussion of bioidentical hormone therapy). Other chapters cover the disease mechanism and associated pharmacology of drugs for several diseases including cancer, metabolic syndrome, diabetes, heart disease, stroke, osteoporosis, neurodegenerative diseases, the immune system and much more. The new edition also includes an overview of emergent medical problems and possible solutions (such as the flu, ebola virus, global climate change, a shortage of medicines, genetic engineering and stem cell therapy). Drugs that have been approved by the FDA since the 1st edition was written are also included. The book concludes with an explanation of systems thinking in medicinal chemistry, an important, yet rarely explored topic in other medicinal chemistry text books.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, EBSCO.


As a practicing physician, I found this third edition to be very up-to-date, interesting and useful. It would be an excellent text book for the second semester in the standard twosemester course taught at most pharmacy schools. I was especially impressed with the first chapter on predictive, preventive, personalized and participatory (P4) medicine. It epitomizes the fusion of traditional and western medicine. That is, mathematics, the foundation of reductionist thinking, is used to quantify huge datasets from patients, while physicists, chemists, biologists and engineers develop the analytical tools needed to generate the data. All of this can be linked through the internet and used in mobile healthcare applications. Also, the book concepts and metabolic processes for which there was limited knowledge or was completely unknown when I was a medical student. The information presented provides undergraduate, medical and pharmacy students with useful information about the indications for and applications of modern medicinal chemistry. It will also prepare currently licensed physicians prepare for Board certification and recertification. Many of the old questions may have new answers. I also found the book to be very helpful in describing medicines that I currently prescribe to patients and new drugs that are being developed. On frequent occasions, a patient will ask, “Why aren’t doctors doing more to find cures for common diseases”. The information in this book provides useful answers. I am also frequently asked questions about nutrition, dietary supplements and environmental toxins. The information about these subjects was written in clear, simple language that most people can understand. For example, I am frequently asked if it is beneficial to take the popular supplement, açaí, to help lose weight. Not being from Brazil, I didn’t know anything about it. This book talks about how açaí is 50% fat, as triglycerides. It is an excellent source of calories and antioxidants for undernourished natives and highly competitive athletes who need more calories. Taking açaí will actually make you gain weight. So, the book is very readable and has a multi-disciplinary approach. It teaches the kind of things that I would like to see medical and pharmacy students learn and could even be useful to lay people.

Mark D. Pilley
M.D. P.O. Box 241723
NE 68124-3135


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