Authors: Qigui Li, Mark R. Hickman

Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy

eBook: US $129 Special Offer (PDF + Printed Copy): US $239
Printed Copy: US $175
Library License: US $516
ISBN: 978-1-68108-055-0 (Print)
ISBN: 978-1-68108-054-3 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810805431150101

Introduction

Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.

Foreword

- Pp. i
Robert M. Paris
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Preface

- Pp. iii
Qigui Li and Mark R. Hickman
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Acknowledgements

- Pp. v
Qigui Li and Mark R. Hickman
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Introduction

- Pp. vii-xi (5)
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Current Issues in Antimalarial Drug Resistance

- Pp. 3-30 (28)
Qigui Li and Mark R. Hickman

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Currently Used Antimalarial Drug Combination Therapies

- Pp. 31-62 (32)
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Clinical Significance of Antimalarial Combinations

- Pp. 63-94 (32)
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Pharmacokinetics (PK) and Pharmacodynamics (PD) of Antimalarial Drugs

- Pp. 95-148 (54)
Qigui Li and Mark R. Hickman

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PK/PD Evaluations of Antimalarial Drugs and Their Combinations

- Pp. 149-218 (70)
Qigui Li and Mark R. Hickman

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Use of PK/PD Assessments for Selecting the Best ACTs

- Pp. 219-265 (47)
Qigui Li and Mark R. Hickman

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PK/PD Modeling of Antimalarial Drug Combinations

- Pp. 267-339 (73)
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Population PK/PD of Antimalarial Combinations

- Pp. 341-394 (54)
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Combination Therapy to Avoid Antimalarial Drug Toxicity

- Pp. 395-440 (46)
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Efforts to Improve Antimalarial Combination Therapy

- Pp. 441-482 (42)
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Conclusion

- Pp. 483-485 (3)
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References

- Pp. 487-515 (29)
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Subject Index

- Pp. 517-529 (13)
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