Editors: Ralph A. Tripp, Jon M. Karpilow

Frontiers in RNAi

Volume 1

Special Offer (PDF + Printed Copy): US $153
Printed Copy: US $119
ISSN: 2589-2932 (Print)
ISSN: 2352-8400 (Online)
ISBN: 978-1-60805-941-6 (Print)
ISBN: 978-1-60805-940-9 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080594091140101

Introduction

RNA Interference (RNAi) arrived in the scientific community just over a decade ago, and has since blossomed with new connections being made between post-transcriptional gene regulation and such topics as innate immunity, epigenetics, and genome organization. Simultaneously, RNAi “the tool” has facilitated research in countless areas, expanding our understanding of cancer, virology, and stem cell biology while challenging the reliability of in vitro systems to accurately model normal and disease physiology. The contributions of RNAi are expected to grow over the next decade in part due to the current ability to map the host-pathogen interface using RNAi to identify previously unknown interactions. Continued studies of lncRNAs and miRNAs, particularly as they are associated with target identification, are expected to expand our understanding of non-coding RNAs and lead to a more integrated and comprehensive theory of gene modulation. RNAi is currently being used to enhance bioproduction platforms and bioprocessing, a feature that will change the paradigm of biotechnology and drive economic growth in such fields as vaccine development, biofuel production, and industrial manufacturing. There is currently a keen need for expert literature that details recent advances and applications of RNAi technology. The publication being proposed herein will draw upon the expertise of the RNAi Global Initiative (RGI), a worldwide academic-industrial consortium comprised of over fifty universities, all focused on high-throughput genome-wide RNAi screening. With expertise in cancer biology, bioinformatics, host-pathogen biology, bioproduction, as well as RNA biology and chemistry, RGI, together with additional colleagues in academics, government, and industry, is well positioned to provide up-to-date perspectives on the advances and challenges facing the scientific community.

Contributors

Editor(s):
Ralph A. Tripp
Department of Infectious Diseases
University of Georgia
Athens
GA
USA


Jon M. Karpilow
Biosciences Division
Thermo Fisher Scientific
Lafayette
CO
USA




Contributor(s):
Abhijeet Bakre
Department of Infectious Diseases
University of Georgia, College of Veterinary Medicine
111 Carlton Street
Athens
GA 30602
USA


Aideen Long
Department of Clinical Medicine
Trinity College Dublin
Dublin
Ireland


Amanda Birmingham
Dharmacon
part of GE Healthcare
2650 Crescent Dr., Suite, 100
Lafayette
CO 80026
USA


Andreas Kaufmann
LMSC
ETH
Schafmattstrasse 18
8093 Zurich
Switzerland


Andrew G. Bean
CSIRO Australian Animal Health Laboratory
Geelong 3220
Victoria
Australia


Anja Van Brabant Smith
Dharmacon
part of GE Healthcare
2650 Crescent Dr., Suite, 100
Lafayette
CO 80026
USA


Annaleen Vermeulen
Dharmacon
part of GE Healthcare
2650 Crescent Dr., Suite, 100
Lafayette
CO 80026
USA


Arvind Rao
Department of Bioinformatics and Computational Biology
Division of Quantitative Sciences The University of Texas M.D
Anderson Cancer Center
Houston
TX 77054
USA


Cameron R. Stewart
CSIRO Australian Animal Health Laboratory
Geelong 3220
Victoria
Australia


Caroline E. Shamu
ICCB-Longwood Screening Facility
Harvard Medical School
250 Longwood Avenue, SGM Building Room 604
Boston
MA 021155731
USA


Esther E. Schmidt
German Cancer Research Center, Division Signaling and Functional Genomics and Heidelberg University
Department for Cell and Molecular Biology, Medical Faculty Mannheim
Im Neuenheimer Feld 580
69120 Heidelberg
Germany


Geoffrey Bartholomeusz
Department of Experimental Therapeutics
Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center
Houston
TX. 77054
USA


HiChul Kim

Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


Iain D.C. Fraser
Signaling Systems Unit, Laboratory of Systems Biology
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda
MD 20892
USA


Jennifer A. Smith
ICCB-Longwood Screening Facility
Harvard Medical School, 250 Longwood Avenue
SGM Building Room 604
Boston
MA 021155731
USA


Jin Y. Kim
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


Jinyeoung Heo
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


John Stambas
Deakin University School of Medicine
Waurn Ponds
Victoria, 3216
Australia


John W. Lowenthal
CSIRO Australian Animal Health Laboratory
Geelong 3220
Victoria
Australia


Jon M. Karpilow
Thermo Fisher Scientific
2650 Crescent Dr., Suite, 202
Lafayette
CO 80026
USA


Karol Kozak
LMSC
ETH
Schafmattstrasse 18
8093 Zurich
Switzerland


Kaylene J. Simpson
Victorian Centre for Functional Genomics
Peter MacCallum Cancer Centre
East Melbourne
Victoria, 3002
Australia


Kristie A. Jenkins
CSIRO Australian Animal Health Laboratory
Geelong 3220
Victoria
Australia


Leonard H. Izzard
Deakin University School of Medicine
Waurn Ponds
Victoria, 3216
Australia


Mark L. Tizard
CSIRO Australian Animal Health Laboratory
Geelong 3220
Victoria
Australia


Michael A. E. Hansen
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


Michael Boutros
Division Signaling and Functional Genomics and Heidelberg University
Department for Cell and Molecular Biology, Medical Faculty Mannheim
Im Neuenheimer Feld 580
69120 Heidelberg
Germany


Michael Freeley
Department of Clinical Medicine
Trinity College Dublin
Dublin
Ireland


Michael S. Banos
Dharmacon
part of GE Healthcare
2650 Crescent Dr., Suite, 100
Lafayette
CO 80026
USA


Namyoul Kim
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


Olivia Perwitasari
Department of Infectious Diseases
University of Georgia, College of Veterinary Medicine
111 Carlton Street
Athens
GA 30602
USA


Paula Brooks
Department of Infectious Diseases
University of Georgia, College of Veterinary Medicine
111 Carlton Street
Athens
GA 30602
USA


Ralph A. Tripp
Department of Infectious Diseases
University of Georgia, College of Veterinary Medicine
111 Carlton Street
Athens
GA 30602
USA


Roderick L. Beijersbergen
Division of Molecular Carcinogenesis, Cancer Genomics Center and Cancer Systems Biology Center
The Netherlands Cancer Institute
1066 CX Amsterdam
The Netherlands


S. Mark Tompkins
Department of Infectious Diseases
University of Georgia
Athens
Georgia
USA


Sabine van der Sanden
Centers for Disease Control and Prevention
600 Clifton Road NE
Atlanta
GA, 30333
USA


Samantha Barichievy
Gene Expression and Biophysics Group
Synthetic Biology Emerging Research Area
Council for Scientific and Industrial Research
Pretoria
South Africa


Sarah B. Anderson
Challenge Technology Inc.
4950 Ward Road
Wheat Ridge
CO 80033
USA


Sean M. Johnston
ICCB-Longwood Screening Facility
Harvard Medical School
250 Longwood Avenue, SGM Building Room 604
Boston
MA 02115
USA


Sinu P. John
Signaling Systems Unit, Laboratory of Systems Biology
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Bethesda
MD 20892
USA


Steven Oberste
Centers for Disease Control and Prevention
1600 Clifton Road NE
Atlanta
GA, 30333
USA


TaeKyu Lee
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


Timothy J. Doran
CSIRO Australian Animal Health Laboratory
Geelong 3220
Victoria
Gyeonggi-do
Australia


Veronica Soloveva
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea


Weilin Wu
Department of Infectious Diseases
University of Georgia, College of Veterinary Medicine
111 Carlton Street
Athens
GA 30602
USA


Yong-Jun Kwon
Institute Pasteur Korea
696 Sampyeong-dong
Bundang-gu
Gyeonggi-do, 463-400
South Korea




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