Authors: Camillo Peracchia, & Nasr H. Anaizi

Lung Function in Health and Disease Basic Concepts of Respiratory Physiology and Pathophysiology

eBook: US $39 Special Offer (PDF + Printed Copy): US $138
Printed Copy: US $119
Library License: US $156
ISBN: 978-1-60805-829-7 (Print)
ISBN: 978-1-60805-828-0 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080582801140101


This reference presents basic concepts relevant to respiratory function in normal and diseased states. The volume stresses a quantitative approach to physical parameters used as indicators of normal and diseased physiological respiratory function. The contents of this reference allow medical students and physiology researchers to become “clinical detectives” - by presenting information that can be useful for enhancing their understanding of the major abnormalities in terms of ventilation, pulmonary blood perfusion, venous admixture, wasted alveolar ventilation, tissue oxygenation, acid-base balance, respiratory mechanics, control of breathing, etc. This book is intended for first and second year medical students as well as for residents and fellows, especially in disciplines such as anesthesiology and pulmonary medicine. In addition, the unique mechanistic approach of this book also provides a useful reference to teachers of respiratory physiology who are not involved in respiratory research or those who have not been specifically trained in organ-system physiology. This book thus fills this gap by providing a modern physiology faculty some tools for learning the “nuts-and-bolts” of lung physiology and associated respiratory care

Indexed in: Book Citation Index, Science Edition, EBSCO.


We now have an unprecedented understanding of the cellular and molecular basis of lung function in health and disease. The lung is made of dozens of different cell types, which integrate signals from other body systems to maintain homeostasis. Although the lung has the remarkable ability to rapidly adapt to environmental stressors, compensatory mechanisms can be overwhelmed leading to disease states. Despite recent advances in the cellular and molecular analysis of lung structure and function, an integrated understanding of lung physiology is the cornerstone upon which all other knowledge rests. This new book fulfills this vital role and provides a step-by-step explanation of key aspects of pulmonary physiology.

Written by a team of experts with decades of teaching experience, the authors’ passion for their subject is apparent from the first page. Chapter 1 provides an illuminating yet concise review of how the lung was viewed through history, and culminates in the “golden decades” of 1940-1970 when key theoretical and practical aspects of pulmonary physiology were established by pioneers in the field. Subsequent chapters cover basic principles of lung structure, respiratory mechanics, gas exchange, gas transport, acid-base balance, ventilation-perfusion distribution, control of breathing and respiration during exercise at sea level and high altitude. Although the concepts covered are not new, the authors’ experience in teaching complex concepts shines through in the numerous practical examples and detailed illustrations.

This ebook will be a useful resource for medical students, residents and trainees specializing in pulmonary medicine. Whether encountering dyspneic patients in the outpatient clinic, or managing intubated patients with respiratory failure, a solid understanding of the concepts contained in this ebook will provide the practitioner the insights and confidence needed to provide effective medical care.

Steve N. Georas
University of Rochester
School of Medicine and Dentistry
Rochester, NY