Editors: "Eva M. Brandtner", "John Austin Dangerfield"

Bioencapsulation of Living Cells for Diverse Medical Applications

Personal Book: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library Book: US $316
ISBN: 978-1-60805-721-4
eISBN: 978-1-60805-720-7 (Online)
DOI: 10.2174/97816080572071130101

Introduction

Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells.

This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Contributors

Editor(s):
Eva M. Brandtner
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT)
Austria


John Austin Dangerfield
SG Austria / Austrianova Singapore
Singapore




Contributor(s):
Jean-Pierre Abastado
Singapore Immunology Network (SIgN)
8A Biomedical Grove, Immunos Building, Level 4
Singapore


Shigeki. Arii
Department of Hepato-Biliary-Pancreatic Surgery
Graduate School of Medicine, Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku
Tokyo, 113-8519
Japan


Stéphanie Bilodeau
Université de Montréal / Centre de Recherche de l’Hôpital Maisonneuve-Rosemont
Research Laboratory on Bio-artificial Therapies
5415 boul. L’Assomption
Montréal (Québec), H1T 2M4
Canada


Eva Maria Brandtner
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT)
Molecular Biology Laboratory
Stadtstrasse 33
Dornbirn, A-6850
Austria


Randolph Corteling
ReNeuron Limited
10 Nugent Road, Surrey Research Park, Guildford
Surrey, GU2 7AF
UK


Thomas Czerny
Department for Applied Life Sciences
University of Applied Sciences, FH Campus Wien
Helmut-Qualtinger-Gasse 2
Vienna, A-1030
Austria


John Austin Dangerfield
SG Austria / Austrianova Singapore
20 Biopolis Way, #05-518 Centros
Singapore


Jayne Foster
Former Diabetes Transplant Unit
Prince of Wales Hospital & University of New South Wales
Sydney
Australia


Walter Gunzburg
SG Austria / Austrianova Singapore
20 Biopolis Way, #05-518 Centros
Singapore
/
Institute of Virology in the Department of Pathobiology
University of Veterinary Medicine
Vienna, A-1220
Austria


Jean-Pierre Hallé
Université de Montréal / Centre de Recherche de l’Hôpital Maisonneuve-Rosemont / Research Laboratory on Bio-artificial Therapies
5415 boul. L’Assomption
Montréal (Québec), H1T 2M4
Canada


Rosa Martin Hernández
NanoBioCel Group, Laboratory of Pharmaceutics
University of the Basque Country, School of Pharmacy
Vitoria-Gasteiz
Spain


Cornelius Kaspar
Department for Pathobiology
Institute of Virology, University of Veterinary Medicine
Veterinärplatz 1
Vienna, A-1210
Austria


Koei Kawakami
Department of Chemical Engineering
Faculty of Engineering, Kyushu University
744 Motooka, Nishi-ku
Fukuoka, 819-0395
Japan


Tania López-Méndez
NanoBioCel Group, Laboratory of Pharmaceutics
University of the Basque Country, School of Pharmacy
Vitoria-Gasteiz
Spain


Ainhoa Murua
NanoBioCel Group, Laboratory of Pharmaceutics
University of the Basque Country, School of Pharmacy
Vitoria-Gasteiz
Spain
/
Networking Biomedical Research Center on Bioengineering
Biomaterials and Nanomedicine, CIBER-BBN
Vitoria-Gasteiz
Spain
/
Laboratory of Pharmaceutical Technology
School of Pharmacy, University of the Basque Country
Paseo de la Universidad street 7
Vitoria-Gasteiz, 01006
Spain


Gorka Arroyo Orive
NanoBioCel Group, Laboratory of Pharmaceutics,
University of the Basque Country, School of Pharmacy
Vitoria-Gasteiz
Spain


Viktoria Ortner
Department for Applied Life Sciences
University of Applied Sciences, FH Campus Wien
Helmut-Qualtinger-Gasse 2
Vienna, A-1030
Austria


José Luis Pedraz Muñoz
NanoBioCel Group, Laboratory of Pharmaceutics
University of the Basque Country, School of Pharmacy
Vitoria-Gasteiz
Spain


Brian Salmons
SG Austria / Austrianova Singapore
20 Biopolis Way, #05-518 Centros
Singapore


Sakai Shinji
Department of Materials Science and Engineering,
Graduate School of Engineering Science, Osaka University
1-3 Machikaneyama-cho, Toyonaka
Osaka, 560-8531
Japan


John Sinden
ReNeuron Limited
10 Nugent Road, Surrey Research Park, Guildford
Surrey, GU2 7AF
UK


Shinji Tanaka
Department of Hepato-Biliary-Pancreatic Surgery
Graduate School of Medicine, Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku
Tokyo, 113-8519
Japan


Bernard Tuch
Biomedical Materials & Devices, Materials
Science & Engineering, Commonwealth Scientific & Industrial Research Organization (CSIRO)
Riverside, Life Science Centre
11 Julius Avenue
North Ryde, NSW 2113
Australia
/
former Diabetes Transplant Unit
Prince of Wales Hospital & University of New South Wales
Sydney
Australia


Vijayaganapathy Vaithilingam
Biomedical Materials & Devices, Materials
Science & Engineering, Commonwealth Scientific & Industrial Research Organization (CSIRO)
Riverside, Life Science Centre
11 Julius Avenue
North Ryde, NSW 2113
Australia
/
former Diabetes Transplant Unit
Prince of Wales Hospital & University of New South Wales
Sydney
Australia




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