Editors: Marcel Popa , Constantin V. Uglea

Polymeric Nanomedicines

eBook: US $169 Special Offer (PDF + Printed Copy): US $287
Printed Copy: US $203
Library License: US $676
ISBN: 978-1-60805-628-6 (Print)
ISBN: 978-1-60805-484-8 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080548481130101

Introduction

Over the last few decades, numerous nanoparticle platforms have been studied for their use in therapeutic applications. This book deals with the description of the construction of technical systems that combines different functionalities which bring liposomes, polymer-drug conjugates, polymer-protein conjugates, dendrimers, polymeric micelles, polymerosomes and other nanoparticles into the realm of nanotechnology proper, as opposed to traditional pharmacology or supramolecular chemistry. The volume additionally covers topics such as passive and active targeting, the strategies used for drug targeting, and the synthesis and characterization of polymeric nanoparticle platforms. Targeted polymeric nanomedicines have shown exciting results in preclinical studies, demonstrating their potential as therapeutic carriers. Therefore, the development of polymeric nanomedicines as therapeutic agents has generated great enthusiasm both in academia and industry.

The book is systematically divided into chapters devoted to a class of polymeric nanomedicines. Each chapter also describes relevant aspects relating to drug design and targeting of polymeric nanomedicines wherever possible.

In addition, a series of chapters concerning the contribution of polymeric nanomedicines in the treatment of several categories of diseases including cancer, inflammatory, renal, immunological diseases, and brain disorders is also presented.

Key features of this book include:

- A comprehensive and cutting-edge overview of polymeric nanomedicines available in a single dedicated volume

- Discussions on advances in drug delivery systems for a variety of diseases

- more than 2000 references, tables, equations, and drawings

Readers, whether beginners or experts, will find in this book, contemporary and relevant information regarding the synthesis, evaluation and applications of polymeric nanomedicines. Supplemented with extensive bibliographic references, tables and figures, this book is an essential and incomparable reference for medicinal chemists, biologists, and medical (oncologic) researchers, as well as for scientists, undergraduate and graduate students in the field of medical bioengineering and polymer nanoscience.

Foreword

- Pp. i-ii (2)
Raphael M. Ottenbrite
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Preface

- Pp. iii-iv (2)
Marcel POPA and Constantin V. UGLEA
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List of Contributors

- Pp. v-vii (3)
Marcel POPA and Constantin V. UGLEA
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Nanotechnology and Nanomedicine

- Pp. 3-63 (61)
Marcel Popa and Constantin V. Uglea

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Physical and Biological Targeting

- Pp. 64-118 (55)
Constantin V. Uglea and Marcel Popa

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Biomedical Evaluation and Toxicity of Polymeric Nanomedicines

- Pp. 119-143 (25)
Constantin V. Uglea

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Targeting Moieties

- Pp. 144-189 (46)
Constantin V. Uglea and Marcel Popa

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Polymer-Drug Conjugates

- Pp. 190-232 (43)
Marcel Popa and Constantin V. Uglea

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Dendrimers: A New Tool for Drug Administration

- Pp. 233-250 (18)
Constantin V. Uglea and Marcel Popa

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Polymeric Micelles

- Pp. 251-292 (42)
Ioan I. Negulescu and Constantin V. Uglea

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Liposomal Formulations for Treatment of Carcinoma

- Pp. 293-316 (24)
Anca N. Cadinoiu and Cătălina A. Peptu

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Polymersomes-Preparation, Characterization and Medical Applications

- Pp. 317-339 (23)
Daniela Ailincăi and Marcel Popa

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Polymeric Nanoparticles for Drug Delivery to the Brain

- Pp. 340-411 (72)
Silvia Vasiliu, Cristina D. Vlad, Stefania Racovita, Maria-Andreea Lungan, Lucian Eva and Raluca Munteanu

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Polymeric Nanocapsules

- Pp. 412-449 (38)
Mihaela Holban, Delia Iurea (Raţă) and Marcel Popa

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Polymeric Nanomedicines and Bladder Cancer Therapy

- Pp. 450-471 (22)
Constantin V. Uglea

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Polymeric Nanomedicines as a Treatment of Renal Diseases

- Pp. 472-491 (20)
Ovidiu Novac and Marcel I. Popa

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Modified Pharmaceutical Dosage Forms for Colon Targeted Release

- Pp. 492-542 (51)
Lacramioara Ochiuz

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Polymeric Nanomedicines in Pulmonary Delivery

- Pp. 543-580 (38)
Stefania Racovita, Cristina D. Vlad and Silvia Vasiliu

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Polymeric Nanomedicines in the Therapy of Inflammatory Diseases

- Pp. 581-640 (60)
Lacramioara Ochiuz

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Advances in Nanoophthalmology

- Pp. 641-670 (30)
Cătălina A. Peptu, Dănuţ Costin, Anca N. Cadinoiu, Gabriela Lupescu (Andrei) and Marcel Popa

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Nanomedical Devices for Transdermal Drug Delivery

- Pp. 671-697 (27)
Cristian Peptu and Leonard Ignat

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Nanomaterials and Cardiovascular Implants

- Pp. 698-733 (36)
Constantin V. Uglea and Marcel Popa

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Nanoparticulate Systems in Orthopedic Surgery and Bone Disease Treatment

- Pp. 734-782 (49)
Paul Botez

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Polymeric Nanomedicines: Between Tradition and Innovation

- Pp. 783-790 (8)
Ioan I. Negulescu, Constantin V. Uglea and Marcel Popa

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Index

- Pp. 791-810 (20)
Marcel Popa and Constantin V. Uglea
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