Editors: Klaus Podar, Kenneth C. Anderson

Multiple Myeloma - A New Era of Treatment Strategies

eBook: US $29 Special Offer (PDF + Printed Copy): US $133
Printed Copy: US $119
Library License: US $116
ISBN: 978-1-60805-609-5 (Print)
ISBN: 978-1-60805-297-4 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080529741120101

Introduction

Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced disruption of the bone marrow homeostasis between the highly organized cellular and extracellular compartments supports MM cell proliferation, survival, migration, and drug resistance via activation of various signaling pathways. Based on this knowledge, the prototypic drugs thalidomide, bortezomib, and lenalidomide, which target both MM cells and the bone marrow microenvironment, have already fundamentally changed treatment options of this disease. Indeed, their benefit is now not only shown in relapsed and refractory disease but they also improve overall response, duration of response, and progression-free and overall survival when used as part of first-line regimens. However, despite new insights into MM pathogenesis and exciting derived therapeutic advances, MM still remains incurable. Ongoing studies are therefore aiming to further delineate mechanisms of MM pathogenesis within the bone marrow to identify novel agents with enhanced cytotoxicity and decreased drug resistance to improve patient outcome.

Multiple Myeloma - A New Era of Treatment Strategies is devoted to contributions from eminent scientists providing readers with comprehensive accounts of the most recent developments in the field of MM research. It addresses the interests of scientists and clinical investigators in MM research as well as other fields of oncology, in which the microenvironment is believed to play an important role.

Indexed in: Book Citation Index, Science Edition, Web of Science, Scopus, EBSCO.

Contributors

Editor(s):
Klaus Podar
Dana-Farber Cancer Institute (DFCI)
Harvard Medical School
USA


Kenneth C. Anderson
Dana-Farber Cancer Institute (DFCI)
Harvard Medical School
USA




Contributor(s):
Kenneth C. Anderson
Kraft Family Professor of Medicine
Medical Director, Kraft Family Blood Center
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Brenda M. Birmann
Instructor in Medicine/ Harvard Medical School
Channing Laboratory
Department of Medicine
Brigham and Women's Hospital and Harvard Medical School
Boston
MA
USA


Dharminder Chauhan
Principal Associate in Medicine
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Brian C.-H. Chiu
Associate Professor of Epidemiology, Department of Health Studies
University of Chicago
USA


Wendy Cozen
Associate Professor of Preventive Medicine and Pathology
Department of Preventive Medicine and Pathology
Norris Comprehensive Cancer Center
Keck School of Medicine
University of Southern California
Los Angeles
CA
USA


Michela Frenquelli
Postdoctoral Fellow
Division of Molecular Oncology
San Raffaele del Monte Tabor Scientific Foundation
Milan
Italy


Mariateresa Fulciniti
Postdoctoral Fellow
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Irene Ghobrial
Assistant Professor of Medicine, Department of Medicine
Harvard Medical School
Kirsch Lab for Waldenstrom Macroglobulinemia
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Jean-Luc Harousseau
Professor of Medicine
René Gauducheau Cancer Center
Nantes/ St Herblain
France


Teru Hideshima
Principal Associate in Medicine
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Jonathan L. Kaufman
Assistant Professor of Medicine
Department of Hematology and Medical Oncology Winship Cancer Institute
Emory University School of Medicine
Atlanta
GA
USA


Shaji Kumar
Associate Professor of Medicine, Department of Medicine
Division of Hematology
Mayo Clinic
Rochester
MN
USA


Robert A. Kyle
Professor of Medicine, Department of Medicine
Division of Hematology
Mayo Clinic
Rochester
MN
USA


Jacob P. Laubach
Instructor in Medicine, Department of Medicine
Harvard Medical School
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Suzanne Lentzsch
Assistant Professor of Medicine
Division of Hematology/Oncology
University of Pittsburgh Cancer Institute
Pittsburgh
PA
USA


Sagar Lonial
Associate Professor of Medicine, Vice Chair of Clinical Affairs
Department of Hematology and Medical Oncology Winship Cancer Institute
Emory University School of Medicine
Atlanta
GA
USA


Kristin Muench
Research Associate, Department of Preventive Medicine
Norris Comprehensive Cancer Center
Keck School of Medicine
University of Southern California
USA


Paola Neri
Postdoctoral Fellow
Division of Hematology and Bone Marrow Transplant
University of Calgary
AB
Canada


Klaus Podar
Associate Professor of Medicine
Principal Investigator and Group Leader at the National Center for Tumor Diseases (NCT)
University of Heidelberg and German Cancer Research Center (DKFZ)
Germany
/
Visiting Professor at The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Noopur Raje
Associate Professor of Medicine
Division of Hematology-Oncology
Massachusetts General Hospital Cancer Center
Harvard Medical School
Boston
MA
USA


Paul G. Richardson
Associate Professor of Medicine
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology
Dana Farber Cancer Institute
Harvard Medical School
Boston
MA
USA


Aldo Roccaro
Research Scientist/Research Associate in Medicine
Harvard Medical School
Dana-Farber Cancer Institute
Boston
MA
USA


Giuseppe Rossi
Director of Hematology
Spedali Civili di Brescia
Brescia
Italy


Domenico Ribatti
Professor of Medicine
Department of Human Anatomy and Histology
Bari
Italy


David P. Steensma
Lecturer on Medicine, Department of Medicine
Harvard Medical School
Oncology, Brigham And Women's Hospital
Boston
MA
USA


Catherine A. Suppan
Research Assistant
Channing Laboratory
Department of Medicine
Brigham and Women's Hospital
Boston
MA
USA


Pierosandro Tagliaferri
Professor of Medicine
Medical Oncology Unit
University of Magna Græcia and T. Campanella Cancer Center
Catanzaro
Italy


Pierfrancesco Tassone
Professor of Medicine
Medical Oncology Unit
University of Magna Græcia and T. Campanella Cancer Center
Catanzaro
Italy


Giovanni Tonon
Head, Functional Genomics of Cancer Unit
Division of Molecular Oncology
Scientific Coordinator
Multiple Myeloma Unit
Department of Oncology
San Raffaele del Monte Tabor Scientific Foundation
Milan
Italy


Angelo Vacca
Professor of Medicine
Department of Internal Medicine and Clinical Oncology
Bari
Italy


Sonia Vallet
Postdoctoral Fellow
Division of Hematology-Oncology
Massachusetts General Hospital Cancer Center
Harvard Medical School
Boston
MA
USA




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