Editor: Kuldip S. Sidhu

Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISBN: 978-1-60805-533-3 (Print)
ISBN: 978-1-60805-289-9 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080528991120101

Introduction

Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potential. The procedure employs pluripotent stem cells as these have the inherent ability to reproduce indefinitely and have the ability to produce over 200 different types of cells constituting the human body. The isolation of human embryonic stem cells (hESCs) from embryos and their successful culture in a petri dish in 1998 has been considered as a major breakthrough that is set to shape stem cell research in the 21st century. This has been followed by another remarkable breakthrough in 2006 when scientists demonstrated for the first time that such pluripotent stem cells could be produced from adult somatic tissues without having to use human embryos. These pluripotent stem cells are called the induced pluripotent stem (iPS) cells. Both hESCs and iPS cells - highly versatile cells – could pave the way for alleviating patients suffering from diabetes, Parkinson’s disease, Alzheimer’s disease, and many more.

This eBook brings together the information from the last decade on stem cells, compiled by reputed research experts. Readers will learn all aspects of pluripotent stem cells from basic biology to their use in understanding disease process, toxicology, drug discovery and in developing therapeutic strategies. Research on these cells, including transitional and translational aspects, is explained with the aid of extensive figures, colour photographs, and tables.

This eBook is a valuable resource for undergraduates, postgraduates, scientists, embryologists, tissue engineers, doctors and biomedical scientists interested in stem cell research and medicine.

Indexed in: Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, Scopus, EBSCO.

Foreword

- Pp. i
Glyn Stacey
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Preface

- Pp. ii-iii (2)
Kuldip S. Sidhu
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List of Contributors

- Pp. iv-ix (6)
Kuldip S. Sidhu
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Stem Cells, Definition, Classification and Sources

- Pp. 3-15 (13)
Kuldip S. Sidhu, Methichit Chayosumrit and Khun H. Lie

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Therapeutic Cloning: Derivation and Propagation of Embryonic Stem Cells by Somatic Cell Nuclear Transfer

- Pp. 16-29 (14)
Zichuan Liu, Shuya Zhou, Shun Zhang, Baolong Xia and Qi Zhou

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Characterization of Human Embryonic Stem Cells

- Pp. 30-40 (11)
Romulo M. Brena

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Generation of Pluripotent Stem Cells and their Developmental Potential

- Pp. 41-55 (15)
Brock J. Conley, Mark Denham, Martin F. Pera and Mirella Dottori

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Genome, Epigenome and Transcriptome Profiling of Pluripotent Stem Cells

- Pp. 56-67 (12)
Henry Chung and Kuldip S. Sidhu

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Modelling Differentiation of Pluripotent Stem Cells to the Three Germ Layers

- Pp. 68-82 (15)
Michael B. Morris

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Stem Cells and Translational Medicine: Ethics, Law, and Policy

- Pp. 83-94 (12)
Loane Skene

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Pluripotent Stem Cells & Neurodegenerative and Ischaemic Brain Diseases: Basic Science to Clinical Applications

- Pp. 95-112 (18)
Kuldip S. Sidhu and Perminder S. Sachdev

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Pluripotent Stem Cells - A Novel Source of Haematopoietic Cells for Transplantation and Transfusion Medicine

- Pp. 113-142 (30)
Catalina A. Palma, David Ma and Robert Lindeman

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Pluripotent Stem Cells and Diabetes: Basic Science to Clinical Applications

- Pp. 143-167 (25)
Khun H. Lie, Methichit Chayosumrit, Anand Hardikar and Kuldip S. Sidhu

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Stem Cells and Ocular Disorders: Basic Science to Clinical Applications

- Pp. 168-179 (12)
Indumathi Mariappan, Subhash Gaddipati, Taraprasad Das, Geeta K. Vemuganti and Virender S. Sangwan

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Micro-RNAs, Pluripotent Stem Cells and Germ Cells: Basic Science to Clinical Applications

- Pp. 180-190 (11)
Jinlian Hua, Shun Zhang, L. Wang, H. Cao, H. Zhu, J. Sun and Kuldip S.Sidhu

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Stem Cell Technologies and their Application in Modern Toxicology- Current State of the Art

- Pp. 191-204 (14)
Martina Klarić, Roberto E.-Waser, Kinga Vojnits and Susanne B.-Hoffmann

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Pluripotent Stem Cells for (Neurodegenerative) Disease Modelling

- Pp. 205-219 (15)
Greg T. Sutherland and Kuldip S. Sidhu

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Stem Cell Therapy in Alzheimer’s Disease Models: Neurogenesis Versus Trophic Support

- Pp. 220-226 (7)
Jürgen Götz and Sven Büttner

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The Prospects and Challenges of Cell-Based Therapies

- Pp. 227-233 (7)
Kuldip S. Sidhu

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Subject Index

- Pp. 234-237 (4)
Kuldip S. Sidhu
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