Editor: Adit B.-Baruch

The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis

eBook: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library License: US $316
ISBN: 978-1-60805-520-3 (Print)
ISBN: 978-1-60805-256-1 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080525611120101

Introduction

Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious microenvironmental factors. The tumor microenvironment contains stroma cells and leukocytes, soluble factors and matrix components. The intensive interplay that exists between the host factors and the tumor cells plays a major role in dictating the final outcome of the malignant process.

Inflammatory mediators are pivotal microenvironmental factors present in the tumor milieu. These inflammatory components support cell growth and invasion, induce mutagenesis, increase angiogenicity, and suppress potential anti-tumor immune functions. The inflammatory constituents that prevail in tumors include leukocytes and soluble mediators - cytokines and chemokines.

This e-book describes the roles played by these mediators in malignancy, and explains the basis for their consideration as therapeutic targets in cancer.

The e-book is a timely overview of the roles played by inflammatory soluble mediators in neoplastic diseases. The topics addressed in this volume serve as a handy reference to investigators studying basic aspects of the malignant tumor growth, to clinicians who wish to better understand the processes involved in malignancy, and to pharmacological professionals seeking novel candidates for therapeutic intervention in cancer.

Indexed in: Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, Scopus, EBSCO.

Contributors

Editor(s):
Adit B.-Baruch
Tel Aviv University
Israel




Contributor(s):
Sivan Izraely
Department of Cell Research and Immunology
George S. Wise Faculty of Life Sciences
Tel Aviv University
Tel Aviv
Israel


Isaac P. Witz
Department Cell Research and Immunology
George S. Wise Faculty of Life Sciences
Tel Aviv University
Tel Aviv, 69978
Israel


Paola Larghi
Istituto Clinico Humanitas
IRCCS, 20089 Rozzano
Milan
Italy


Chiara Porta
DISCAFF
University of Piemonte Orientale A. Avogadro
Novara, 28100
Italy


Elena Riboldi
DISCAFF
University of Piemonte Orientale A. Avogadro
Novara, 28100
Italy


Paola Allavena
Istituto Clinico Humanitas
IRCCS Milan
Rozzano, 20089
Italy


Alberto Mantovani
Istituto Clinico Humanitas
IRCCS Milan
Rozzano, 20089
Italy


Antonio Sica
Istituto Clinico Humanitas
IRCCS Milan
Rozzano, 20089
Italy


Loris Bertazza
Department of Oncological & Surgical Sciences
Section of Clinica Chirurgica 2 University of Padova
via Giustiniani 2
Padua, 35128
Italy


Simone Mocellin
Department of Oncological & Surgical Sciences
Section of Clinica Chirurgica 2 University of Padova
via Giustiniani 2
Padua, 35128
Italy


Mark DeWitte
Haematology / Oncology Clinical R&D CSL Ltd
45 Poplar Road Parkville
VIC, 3052
Australia


Donato Nitti
Department of Oncological & Surgical Sciences
Section of Clinica Chirurgica 2 University of Padova
via Giustiniani 2
Padua, 35128
Italy


Elena Voronov
Department of Microbiology and Immunology
University Ben Gurion of the Negev
Beer-Sheva, 84105
Israel


Ron N. Apte
The Shraga Segal Department of Microbiology and Immunology
Faculty of Health Sciences
Ben-Gurion University of the Negev
Beer-Sheva, 84105
Israel


Ellen C. Keeley
Department of Medicine
Division of Cardiology
University of Virginia
Charlottesville
Virginia
USA


Borna Mehrad
Departments of Medicine and Microbiology
Pulmonary and Critical Care Medicine
University of Virginia
Charlottesville
Virginia
USA


Robert M. Strieter
University of Virginia
Department of Medicine
Division of Pulmonary Critical Care, Box 800466
Charlottesville
Virginia , 22908-0466
USA


Yanchun Li
Marlene and Stewart Greenebaum Cancer Center and Department of Pathology
University of Maryl and School of Medicine
USA


Amy Fulton
Department of Pathology
University of Maryland, Greenebaum Cancer Center
University of Maryland, School of Medicine
9th Floor, 655 W. Baltimore St.
Baltimore
MD, 21201
USA


Adit Ben-Baruch
Department of Cell Research and Immunology
George S. Wise Faculty of Life Sciences
Tel Aviv University
Tel Aviv, 69978
Israel


Amanda Burkhardt
Department of Physiology and Biophysics
University of California Irvine
Irvine
CA, 92697
USA


Albert Zlotnik
Department of Physiology and Biophysics
University of California Irvine
Irvine
CA, 92697
USA


Dror Luger
Laboratory of Cancer Biology and Genetics
National Cancer Institute
Bethesda
MD, 20892
USA


Lalage M. Wakefield
Laboratory of Cancer Biology and Genetics
National Cancer Institute
Bethesda
MD, 20892
USA


Amnon Peled
Goldyne Savad Institute of Gene Therapy
Hadassah Hebrew University Hospital
P.O. Box 12000
Jerusalem, 91120
Israel




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