Editors: Atta-ur-Rahman, Choudhary M. Iqbal

Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy

Personal Book: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library Book: US $196
ISSN: 2468-6301
ISBN: 978-1-60805-408-4
eISBN: 978-1-60805-164-9 (Online)
Year of Publication: 2011
DOI: 10.2174/97816080516491110101

Introduction

NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parameters which are highly sensitive to the exact environment of the molecules, and therefore yield information about whether a small molecule (candidate compound) binds to a target protein (receptor) or to other macromolecules. These NMR parameters are also used to exactly map the part of the macromolecular target to which the ligand is bound. Spectacular advances in the use of NMR spectroscopy in drug discovery and development have been triggered by a greater understanding of the disease process at the molecular level. Structure – Activity Relationship Studies in Drug Development by NMR Spectroscopy presents comprehensive reviews on NMR spectroscopic drug development written by leading experts in the field.

This ebook will fulfill an important need of the scientific community by providing recent cutting edge knowledge, practices and experiences in pharmaceutical innovation and development.

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan


Prof. Dr. Choudhary M. Iqbal
University of Karachi
Pakistan




Contributor(s):
Raghu Prasad Mailavaram
Department of Pharmaceutical Chemistry
Shri Vishnu College of Pharmacy [Affiliated to Andhra University, Visakhapatnam}
Padmabhushan Dr. B. V Raju Foundation and Sri Vishnu Educational Society, Vishnupur, Bhimavaram, West Godavari District
Andhra Pradesh , 534202
India


Murty Devarakonda
Department of Pharmaceutical Chemistry
Shri Vishnu College of Pharmacy [Affiliated to Andhra University, Visakhapatnam}
Padmabhushan Dr. B. V Raju Foundation and Sri Vishnu Educational Society, Vishnupur, Bhimavaram, West Godavari District
Andhra Pradesh , 534202
India


Soo-Jin Park
Department of Chemistry
Inha University
253 Yonghyun-dong, Nam-gu Incheon
Siena, 402-751
Korea


Ki-Seok Kim
Department of Chemistry
Inha University
253 Yonghyun-dong, Nam-gu Incheon
Siena, 402-751
Korea


Consonni Roberto
Institute for the Study of Macromolecules (ISMAC)
NMR Laboratory, National Council of Research
Milan
Italy


Veronesi Marina
Italian Institute of Technology
Genoa
Italy


V. Raja Solomon
Tumour Biology Group, Northeastern Ontario Regional Cancer Program at the Sudbury Regional Hospital
41 Ramsey Lake Road, Sudbury
Ontario , P3E 5J1
Canada
/
Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury
41 Ramsey Lake Road, Sudbury
Ontario , P3E 2C6
Canada


Hoyun Lee
Tumour Biology Group, Northeastern Ontario Regional Cancer Program at the Sudbury Regional Hospital
41 Ramsey Lake Road, Sudbury
Ontario , P3E 5J1
Canada
/
Department of Biology
Laurentian University, Department of Medical Sciences, the Northern Ontario School of Medicine
935 Ramsey Lake Road, Sudbury
Ontario , P3E 2C6
Canada


Teodorico C. Ramalho
Universidade Federal de Lavras, Campus Universitário – UFLA
Dept. de Química, 37200-000
Lavras
MG
Brazil


Elaine F. F. da Cunha
Universidade Federal de Lavras, Campus Universitário – UFLA
Dept. de Química, 37200-000
Lavras
MG
Brazil


Marcus V. J. Rocha
Universidade Federal de Lavras, Campus Universitário – UFLA
Dept. de Química, 37200-000
Lavras
MG
Brazil


Giorgio Zoppetti
R&D Pharma Department, IBSA Institut Biochimique SA –Via al Ponte 13-6903, Lugano 3 (CH)
Switzerland


Hoang Nam Nhat
Department of Technical Physics and Nanotechnology
UET, Vietnam National University Hanoi
144 Xuan Thuy, Cau Giay
Hanoi
Vietnam


Tran Thi Hong
Department of Technical Physics and Nanotechnology
UET, Vietnam National University Hanoi
144 Xuan Thuy, Cau Giay
Hanoi
Vietnam




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