Editors: Atta-ur-Rahman, Choudhary M. Iqbal

Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISSN: 2468-6301 (Print)
ISBN: 978-1-60805-408-4 (Print)
ISBN: 978-1-60805-164-9 (Online)
Year of Publication: 2011
DOI: 10.2174/97816080516491110101


NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parameters which are highly sensitive to the exact environment of the molecules, and therefore yield information about whether a small molecule (candidate compound) binds to a target protein (receptor) or to other macromolecules. These NMR parameters are also used to exactly map the part of the macromolecular target to which the ligand is bound. Spectacular advances in the use of NMR spectroscopy in drug discovery and development have been triggered by a greater understanding of the disease process at the molecular level. Structure – Activity Relationship Studies in Drug Development by NMR Spectroscopy presents comprehensive reviews on NMR spectroscopic drug development written by leading experts in the field.

This ebook will fulfill an important need of the scientific community by providing recent cutting edge knowledge, practices and experiences in pharmaceutical innovation and development.

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.


- Pp. i-ii (2)
Atta-ur-Rahman, M. Iqbal Choudhary
Download Free


- Pp. iii-iv (2)
Atta-ur-Rahman, M. Iqbal Choudhary
Download Free

NMR-A Gate Way to Drug Discovery

- Pp. 1-35 (35)
Raghu Prasad Mailavaram, Murty Devarakonda
View Abstract

Investigation of Drug Delivery Behaviors by NMR Spectroscopy

- Pp. 36-66 (31)
Soo-Jin Park, Ki-Seok Kim
View Abstract

NMR Screening Methods in Fragment-Based Drug Discovery

- Pp. 67-101 (35)
Consonni Roberto, Veronesi Marina
View Abstract

Utilization of NMR-Based Techniques in Anticancer Drug Development

- Pp. 102-144 (43)
V. Raja Solomon, Hoyun Lee
View Abstract

Targeting NMR Parameters and Dynamics of Radiosensitizers in Solution: Theoretical Studies of Prototypical Some Bioreductive Drugs

- Pp. 145-155 (11)
Teodorico C. Ramalho, Elaine F. F. da Cunha, Marcus V. J. Rocha
View Abstract

Evaluation of Host/Guest Cyclodextrin Complex by NMR in Drug Product Development

- Pp. 156-183 (28)
Giorgio Zoppetti
View Abstract

NMR Studies in Nanoparticle Drug Delivery Systems: Paclitaxel Loaded Nanocarriers

- Pp. 184-213 (30)
Hoang Nam Nhat, Tran Thi Hong
View Abstract

Author Index

- Pp. 214
Atta-ur-Rahman, M. Iqbal Choudhary
Download Free