Editors: Atta-ur-Rahman, Choudhary M. Iqbal

Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISSN: 2468-6301 (Print)
ISBN: 978-1-60805-408-4 (Print)
ISBN: 978-1-60805-164-9 (Online)
Year of Publication: 2011
DOI: 10.2174/97816080516491110101

Introduction

NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parameters which are highly sensitive to the exact environment of the molecules, and therefore yield information about whether a small molecule (candidate compound) binds to a target protein (receptor) or to other macromolecules. These NMR parameters are also used to exactly map the part of the macromolecular target to which the ligand is bound. Spectacular advances in the use of NMR spectroscopy in drug discovery and development have been triggered by a greater understanding of the disease process at the molecular level. Structure – Activity Relationship Studies in Drug Development by NMR Spectroscopy presents comprehensive reviews on NMR spectroscopic drug development written by leading experts in the field.

This ebook will fulfill an important need of the scientific community by providing recent cutting edge knowledge, practices and experiences in pharmaceutical innovation and development.

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-ii (2)
Atta-ur-Rahman and M. Iqbal Choudhary
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Contributors

- Pp. iii-iv (2)
Atta-ur-Rahman and M. Iqbal Choudhary
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NMR-A Gate Way to Drug Discovery

- Pp. 1-35 (35)
Raghu Prasad Mailavaram and Murty Devarakonda

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Investigation of Drug Delivery Behaviors by NMR Spectroscopy

- Pp. 36-66 (31)
Soo-Jin Park and Ki-Seok Kim
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NMR Screening Methods in Fragment-Based Drug Discovery

- Pp. 67-101 (35)
Consonni Roberto and Veronesi Marina
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Utilization of NMR-Based Techniques in Anticancer Drug Development

- Pp. 102-144 (43)
V. Raja Solomon and Hoyun Lee

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Targeting NMR Parameters and Dynamics of Radiosensitizers in Solution: Theoretical Studies of Prototypical Some Bioreductive Drugs

- Pp. 145-155 (11)
Teodorico C. Ramalho, Elaine F. F. da Cunha and Marcus V. J. Rocha

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Evaluation of Host/Guest Cyclodextrin Complex by NMR in Drug Product Development

- Pp. 156-183 (28)
Giorgio Zoppetti

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NMR Studies in Nanoparticle Drug Delivery Systems: Paclitaxel Loaded Nanocarriers

- Pp. 184-213 (30)
Hoang Nam Nhat and Tran Thi Hong

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Author Index

- Pp. 214
Atta-ur-Rahman and M. Iqbal Choudhary
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