Editors: Karoly Tihanyi , Monika Vastag

Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISBN: 978-1-60805-619-4 (Print)
ISBN: 978-1-60805-120-5 (Online)
Year of Publication: 2011
DOI: 10.2174/97816080512051110101

Introduction

This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of drug candidates. The book provides an integrated view of fundamental ADME issues and challenges in early drug development from the aspect of practicing drug researchers. It also provides valuable help for the medicinal chemist in the process of multiple optimization.

Foreword

- Pp. i
Olavi Pelkonen
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Preface

- Pp. ii-iii (2)
Karoly Tihanyi
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Contributors

- Pp. iv-v (2)
K. Tihanyi and M. Vastag
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Recent Advances in ADME Predictions

- Pp. 3-32 (30)
Laszlo Molnar and Gyorgy M. Keseru

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Physicochemical Characterization of NCEs in Early Stage Drug Discovery

- Pp. 33-51 (19)
Gyorgy T. Balogh

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Solubility as a Challenge in Drug Research and Development

- Pp. 52-67 (16)
Attila Sandor Halász

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Preclinical Formulation in Early Drug Research

- Pp. 68-85 (18)
Ottilia Balazs

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Intestinal Absorption and Models of Penetration

- Pp. 86-101 (16)
Eva Hellinger and Monika Vastag

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Membrane and Dye Efflux Assays to Detect and Characterize the Interaction of Drugs with ABC Transporters

- Pp. 102-116 (15)
Eniko Ioja, Zoltan Nagy, Viktoria Juhasz, Judit Janossy, Krisztina Heredi-Szabo and Peter Krajcsi

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Induction and Inhibition of Drug Metabolizing Enzymes

- Pp. 117-143 (27)
Karoly Tihanyi

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Drug Transport and the Blood-Brain Barrier

- Pp. 144-165 (22)
Maria A. Deli

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Tools for Modelling Blood-Brain Barrier Penetrability

- Pp. 166-188 (23)
Szilvia Veszelka, Agnes Kittel and Maria A. Deli

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Cell-Penetrating Peptides and Protein Transduction Domains in Drug Delivery

- Pp. 189-212 (24)
Erno Duda and Tamas Letoha

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Transporterization: A Tool for Drug Delivery to the Central Nervous System

- Pp. 213-228 (16)
Gabor Orgovan and Bela Noszal

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Subject Index

- Pp. 229-232 (4)
K. Tihanyi and M. Vastag
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