Editor: "Eric M.-Rodríguez"

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features

Personal Book: US $59 Special Offer (PDF + Printed Copy): US $148
Printed Copy: US $119
Library Book: US $236
ISBN: 978-1-60805-125-0
eISBN: 978-1-60805-028-4 (Online)
DOI: 10.2174/97816080502841130101

Introduction

The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1;and CB2;receptors) activated by marijuana’s psychoactive principleΔ9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans.

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features;is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: ;

*The genetics of cannabinoid CB1;and CB2;receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. ;

*Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action.

*The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. ;

The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. ;

Contributors

Editor(s):
Dr. Eric M.-Rodríguez
Mayab Anahuac University Merida
Mexico




Contributor(s):
Nissar A. Darmani
Department of Basic Medical Sciences
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences
Pomona
CA, 91766
USA


Seetha Chebolu
Department of Basic Medical Sciences
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences
Pomona
CA, 91766
USA


Miriam Melis
Department of Biomedical Sciences
University of Cagliari
Monserrato
(CA)
Italy


Anna L. Muntoni
C.N.R. Neuroscience Institute-Cagliari
University of Cagliari
Monserrato
(CA)
Italy


Marco Pistis
Department of Biomedical Sciences
University of Cagliari
Monserrato
(CA)
Italy


Hiroki Ishiguro
Yamanashi University
Japan


Claire M. Leonard
William Paterson University
Wayne
NJ, 07470
USA


Susan Sgro
William Paterson University
Wayne
NJ, 07470
USA


Emmanuel S. Onaivi
Department of Biology
William Paterson University
Wayne NJ 07470 and NIDA-IRP
Baltimore
MD, 21224
USA


Dow P. Hurst
Center for Drug Discovery, Department of Chemistry and Biochemistry
University of North Carolina at Greensboro
Greensboro
NC, 27402
USA


Jagjeet Singh
Center for Drug Discovery, Department of Chemistry and Biochemistry
University of North Carolina at Greensboro



Patricia H. Reggio
Department of Chemistry and Biochemistry, UNC Greensboro
Greensboro
NC, 27402
USA


Amanda Borgquist
Department of Basic Medical Sciences
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences
Pomona
CA, 91766
USA


Edward J. Wagner
Department of Basic Medical Sciences
College of Osteopathic Medicine, Western University of Health Sciences
309 E. Second Street
Pomona
CA, 91766
USA


Andrew J. Hill
The School of Chemistry, Food and Nutritional Sciences and Pharmacy
The University of Reading, Whiteknights, Reading
Berkshire, RG53SA
UK


Thomas D. M. Hill
The School of Chemistry, Food and Nutritional Sciences and Pharmacy
The University of Reading, Whiteknights, Reading
Berkshire, RG53SA
UK


Benjamin J. Whalley
The School of Chemistry, Food and Nutritional Sciences and Pharmacy
The University of Reading, Whiteknights, Reading
Berkshire, RG53SA
UK




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