Editor: Eric M.-Rodríguez

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features

eBook: US $59 Special Offer (PDF + Printed Copy): US $148
Printed Copy: US $119
Library License: US $236
ISBN: 978-1-60805-125-0 (Print)
ISBN: 978-1-60805-028-4 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080502841130101

Introduction

The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1;and CB2;receptors) activated by marijuana’s psychoactive principleΔ9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans.

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features;is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: ;

*The genetics of cannabinoid CB1;and CB2;receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. ;

*Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action.

*The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. ;

The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. ;

About the eBook

- Pp. i
Eric Murillo-Rodríguez
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Foreword

- Pp. ii-v (4)
R. Mechoulam
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Preface

- Pp. vi-vii (2)
Eric Murillo-Rodríguez
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Acknowledgements

- Pp. viii
Eric Murillo-Rodríguez
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List of Contributors

- Pp. ix-x (2)
Eric Murillo-Rodríguez
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Cannabinoid Receptor Gene Variations in Neuropsychiatric Disorders

- Pp. 3-24 (22)
Hiroki Ishiguro, Claire M. Leonard, Susan Sgro and Emmanuel S. Onaivi

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The Role of Endocannabinoids and Arachidonic Acid Metabolites in Emesis

- Pp. 25-59 (35)
Nissar A. Darmani and Seetha Chebolu

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On the Cannabinoid Regulation of Energy Homeostasis: Past, Present and Future

- Pp. 60-91 (32)
Amanda Borgquist and Edward J. Wagner

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Structural Biology of Endocannabinoid Targets and Enzymes: Components Tuned to the Flexibility of Endogenous Ligands

- Pp. 92-131 (40)
Dow P. Hurst, Jagjeet Singh and Patricia H. Reggio

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Dynamic Interactions Between Drugs of Abuse and the Endocannabinoid System: Molecular Mechanisms and Functional Outcome

- Pp. 132-163 (32)
Miriam Melis, Anna L. Muntoni and Marco Pistis

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The Development of Cannabinoid Based Therapies for Epilepsy

- Pp. 164-204 (41)
Andrew J. Hill, Thomas D.M. Hill and Benjamin J. Whalley

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Index

- Pp. 205-208 (4)
Eric Murillo-Rodríguez, Emmanuel S. Onaivi, Nissar A. Darmani and Edward Wagner
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