Editor: Claudio Hetz

Protein Misfolding Disorders: A Trip into the ER

eBook: US $59 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $107
Library License: US $236
ISBN: 978-1-60805-575-3 (Print)
ISBN: 978-1-60805-013-0 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080501301090101

Introduction

Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This Ebook gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context.

Foreword

- Pp. i
Laurie H. Glimcher
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Preface

- Pp. ii-iii (2)
Claudio Hetz
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Contributors

- Pp. iv-vi (3)
Claudio Hetz
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Targeting Endoplasmic Reticulum Stress Pathways to Treat Neurological Disorders Associated with Protein Misfolding

- Pp. 1-18 (18)
Danny Galleguillos, Soledad Matus, Vicente Valenzuela, Pamela Valdes, Alexis Martinez, Melissa Nassif, Mauricio Torres, Gabriela Martinez and Claudio Hetz

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The Unfolded Protein Response in Mammalian Cells

- Pp. 19-46 (28)
Sung Hoon Back, Justin R. Hassler and Randal J. Kaufman

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The ER Chaperone GRP78 and Cancer

- Pp. 47-55 (9)
Risheng Ye, Yi Zhang and Amy S. Lee

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Endoplasmic Reticulum Stress and Protein Misfolding in Amyotrophic Lateral Sclerosis

- Pp. 56-76 (21)
A. K. Walker, B. J. Turner and J. D. Atkin

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ER Stress Signaling Network in Pancreatic β-Cells

- Pp. 77-87 (11)
Sonya G. Fonseca and Fumihiko Urano

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Heritable Neurodevelopmental Disorders and Endoplasmic Reticulum Stress

- Pp. 88-93 (6)
Takashi Momoi and Eriko Fujita

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ER Quality Control, ER Stress-Induced Apoptosis, and Neurodegenerative Diseases

- Pp. 94-102 (9)
Hideki Nishitoh, Hisae Kadowaki, Kohsuke Takeda and Hidenori Ichijo

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Role of Alzheimer’s β-Amyloid on Wnt Signaling

- Pp. 103-113 (11)
Nibaldo C. Inestrosa, Catalina Grabowski, Macarena Arrazola, Lorena Varela-Nallar and Enrique M. Toledo

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β-Amyloid Peptide, Endoplasmic Reticulum Stress, and Alzheimer’s Disease

- Pp. 114-126 (13)
Othman Ghribi

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Endoplasmic Reticulum Stress Response in Prion Diseases

- Pp. 127-135 (9)
Abhisek Mukherjee and Claudio Soto

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Autophagy and the Ubiquitin-Proteasome System - Protein Catabolism Comes Full Circle

- Pp. 136-147 (12)
Natalia B. Nedelsky and J. Paul Taylor

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