Targeted Oncometabolism: New Frontiers in Cancer Therapy – Part 2

Editors: Mithun Bhowmick, Pratibha Bhowmick, Prashant Tiwari, Steward Mudenda

Targeted Oncometabolism: New Frontiers in Cancer Therapy – Part 2

ISBN: 979-8-89881-901-9
eISBN: 979-8-89881-900-2 (Online)

Introduction

Metabolic reprogramming allows cancer cells to sustain growth, evade immune surveillance, and resist treatment. This volume moves from the hallmarks of cancer metabolism to its clinical application, examining glycolysis, glutamine, lipid, and nucleotide pathways. It shows how fibroblasts, macrophages, and endothelial cells shape metabolic coupling within the tumor microenvironment, and surveys inhibitors, synthetic lethality, and nanotechnology delivery. Particular attention is given to phytochemicals, metabolomics for biomarker discovery, and precision oncology.


Key Features

  • - Links metabolic hallmarks to therapeutic vulnerabilities.
  • - Examines metabolic crosstalk among tumor, stromal, and immune cells.
  • - Covers phytochemicals as modulators of signaling pathways.
  • - Explains metabolomics, sequencing, and liquid biopsy in precision oncology.
  • - Applies AI and computational modeling to predict treatment outcomes.
  • - Bridges laboratory findings and patient care through trial data.

Target Readership :

Researchers, clinicians, postgraduate students, and pharmaceutical science professionals.

Foreword

Cancer remains a major obstacle in modern medicine, requiring innovative strategies beyond traditional treatments. Our understanding of cancer has shifted from a focus on genetics to a broader perspective that recognizes metabolic reprogramming as a critical feature of tumor development. As precision oncology advances, targeting cancer metabolism has become a promising area for new therapeutic approaches.

I am delighted to present Targeted Oncometabolism: New Frontiers in Cancer Therapy, a comprehensive volume edited by Dr. Mithun Bhowmick, Dr. Pratibha Bhowmick, Dr. Prashant Tiwari and Dr. Steward Mudenda. This book is a vital resource for researchers, clinicians, and academics exploring the complex metabolic changes that drive cancer growth and resistance. Through carefully selected chapters, leading experts explore key aspects of cancer metabolism, including mitochondrial dynamics, lipid metabolism, and metabolic interactions within the tumor microenvironment.

A standout feature of this book is its emphasis on translating metabolic discoveries into practical therapeutic strategies. It covers innovative approaches like metabolic inhibitors, immunometabolism, and synthetic lethality, showcasing the evolving field of cancer treatment and the potential for more precise, effective therapies.

The editors have skillfully brought together diverse perspectives, connecting basic research with clinical applications. Their commitment to advancing oncometabolism is clear in the thorough discussions throughout the book. As cancer treatment progresses, incorporating metabolic vulnerabilities into precision medicine will be crucial for improving patient outcomes.

I am confident that Targeted Oncometabolism: New Frontiers in Cancer Therapy will be an invaluable resource for professionals in cancer research and treatment. It deepens our understanding of cancer metabolism and encourages further innovation in the development of effective therapies. I applaud the editors and contributors for their outstanding work and for delivering such a timely and significant contribution to the scientific community.

Deepak S. Khobragade
Department of Pharmacognosy
Datta Meghe College of Pharmacy
Datta Meghe Institute of Higher Education
(Deemed to be University, Wardha
Maharashtra, India