Organic Synthesis with Dioxiranes

Authors: Keshaba Nanda Parida, Ishita Neogi, Gourab Mohanty, Partha Sarathi Guru

Organic Synthesis with Dioxiranes

ISBN: 979-8-89881-820-3
eISBN: 979-8-89881-819-7 (Online)

Introduction

Organic Synthesis with Dioxiranes offers a comprehensive treatment of dioxirane chemistry, from fundamental mechanisms to advanced applications in precision synthesis. Structured consistently across chapters, it moves from basic dioxirane reactivity and mechanism through general oxidation across functional groups, substrate-specific epoxidation strategies, site-selective C–H functionalization and asymmetric synthesis. Organized by functional group and reaction type rather than mere chronology, it mirrors how practicing chemists actually search reference material. The book functions simultaneously as a conceptual introduction and a practical lookup resource — readable front-to-back to build understanding progressively, or consulted directly for a specific substrate or selectivity need.


Key Features

  • - Consistent chapter template for easy, reference-style navigation.
  • - Organized by functional group and reaction type, not chronology.
  • - Layered selectivity framework: stereospecific, chemoselective, stereoselective, diastereoselective, enantioselective.
  • - Bond-type-first approach to C–H oxygenation strategies.
  • - Clear progression from fundamentals to precision, enantioselective synthesis.

Target Readership :

Synthetic chemists, researchers, and graduate students in organic and mechanistic chemistry.

Foreword

Dioxiranes are three-membered heterocyclic organic peroxides that serve as versatile oxygenation reagents. Their multifaceted applications enhance their utility in various chemical processes. Dioxiranes are primarily accessed by the oxygenation of carbonyl compounds using oxidants like Oxone® and H2O2; the latter are inexpensive and offer methods of green oxidation. Since the first dioxirane was synthesized by Talbott and Thompson in 1972, dioxiranes with advanced structures have been developed and explored either stoichiometrically or catalytically (in situ) for numerous organic transformations. The book collates all aspects of dioxirane chemistry, including historical developments, characterizations, reaction mechanisms, and different applications of the reagent explored over the last five decades, and will be highly relevant at times, when eco-friendly and environmentally benign green methods of chemical transformations are gaining widespread attention. The book will be highly informative for the scientific community looking for material development using green protocols and green organic transformations, and will provide them with a glimpse of what has already been done using the reagent and what possibilities can be explored in this area. Thus, the book will be useful for a wider scientific community

Aslam C. Shaikh
Department of Chemistry
Indian Institute of Technology Ropar
Rupnagar, India