Author: Jayalakshmi Krishnan

Toll-Like Receptors in Vector borne Diseases

eBook: US $39 Special Offer (PDF + Printed Copy): US $63
Printed Copy: US $43
Library License: US $156
ISBN: 978-981-5124-55-2 (Print)
ISBN: 978-981-5124-54-5 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151245451230101


The immune system is highly complex, it senses foreign invaders, thus protecting the body. The adaptive arm of the immune system confers long-term protection, whereas the innate immune system confers immediate protection. The immune system uses pattern recognition receptors that are able to sense the molecular patterns associated with pathogens.

Toll-like receptors (TLRs) are important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity.

This book covers the role of TLRs in several vector-borne Diseases. Starting with an introduction to these diseases, the book explains the different types of receptors involved in these diseases. The diseases are then covered in separate chapters, including: malaria, lymphatic filariasis, visceral leishmaniasis, dengue fever, chikungunya, West Nile fever, and Japanese encephalitis.

The book is a handy reference for researchers and trainees involved in clinical medicine and infection control. It can also serve as supplementary reading material for Students undertaking courses in biotechnology, public health, entomology, immunology, epidemiology, and life sciences.


Researchers and trainees involved in clinical medicine and infection control; Students undertaking courses in biotechnology, public health, entomology, immunology, epidemiology, and life sciences.


This topic is appropriate when we talk about the control of vector-borne diseases as a top priority in the world. Vector-borne diseases are a huge public health problem all over the world. Vectors are organisms that transmit pathogens from infected human to animal or from animal to human, accounting for 17% of Vector-borne diseases (VBDs). Vector-borne diseases such as Malaria, Dengue, Chikungunya, Human African Trypanosomiasis, Leishmaniasis, Japanese encephalitis, Chaga’s diseases, Yellow fever, Leishmaniasis, and Onchocerciasis have become major public health concern affecting more than one billion cases and one million deaths globally. There is an urgent need to control these challenges and state of art techniques and science and technology will take it forward. Toll-like receptors are the primary pattern recognition receptors in the human systems and in eliciting innate immune signalling. Cytokines produced through toll-like receptors activation act as a bridge to elicit an adaptive immune response as well. I appreciate this book's title on toll-like receptors in vector-borne diseases as this book can be read by many researchers, industry persons, policymakers, and academicians and can cater to the needs of the research on these vector-borne diseases.

I convey my best wishes to the editor and hope this book will be a great success.

Sangdun Choi
Department of Molecular Science and Technology,
Dean of Graduate School, Ajou University,