Editors: Ashutosh Kumar Dash, Deepak Kumar

The Role of Chromenes in Drug Discovery and Development

eBook: US $59 Special Offer (PDF + Printed Copy): US $101
Printed Copy: US $71
Library License: US $236
ISBN: 978-981-5124-34-7 (Print)
ISBN: 978-981-5124-33-0 (Online)
Year of Publication: 2023
DOI: 10.2174/9789815124330123010001

Introduction

Chromene is a naturally abundant heterocyclic compound found in alkaloids, tocopherols, terpenes and other compounds. Its derivatives can be used as a scaffold that exhibits pharmacological activity in the human body.

Chromene drugs and related bioactive molecules are the prime focus of this reference. It presents 13 thoroughly researched chapters that comprehensively cover all aspects about the molecule. Starting with a detailed introduction to its role and importance in drug discovery, the book goes into the details of chromene structure, synthesis and pharmacology. Readers can gain knowledge of different commercial medicines based on chromene and its pharmacological activity against different diseases. The elaborate topics in the book will help researchers working on chromene based drugs.

Key highlights of the book include:

- Complete coverage of chromene’s role in nature and drug development with references to historical background and current developments

- References to commercial and preclinical drugs and patents of interest

- Explanation of chromene bioacivity in different diseases (antioxidant, antidiabetic, antinflammatory, antibacterial and antifungal activities, antitumour, immunomodulatory activity)

- Explanation of chromene activity against SARS-Cov2

Preface

- Pp. i
Ashutosh Kumar Dash, Deepak Kumar
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List of Contributors

- Pp. ii-iv (3)

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Chromene and its Importance: Chemistry and Biology

- Pp. 1-16 (16)
Nitin Verma*, Parul Sood, Jitender Singh, Niraj Kumar Jha, Mahesh Rachamalla, Kamal Dua

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Recent Trends of Chromene Syntheses

- Pp. 17-42 (26)
Samarpita Das, Pulkit Asati, Harish K. Indurthi, Ashutosh Kumar Dash, Deepak K. Sharma*

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Diversity-Oriented Synthesis of Chromenes

- Pp. 43-83 (41)
Atul Kumar, Diksha Rajput, Gowsia Jan, Vellaisamy Sridharan*

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Role of Chromene in the Cure of Different Kinds of Human Disease

- Pp. 84-99 (16)
Dheeraj Bisht*, Aadesh Kumar, Ankit Kumar, Rajeshwar Kamal-Kant Arya, Krittika Mukherjee, Mohmmad Rashid

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Naturally Occurring Chromene Containing Molecules and their Isolation Protocols

- Pp. 100-128 (29)
Santosh Kumar Rath, Shweta Ramkar, Preeti K. Suresh*

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Chromenes and Nutraceuticals

- Pp. 129-150 (22)
Vagish Dwibedi, Sahil Jain, Anuradha Mittal, Arti Devi, Harleen Kaur Walia, Santosh Kumar Rath, Paola Andrea Duran Cuevas*

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Pharmacokinetic Aspects of Chromenes

- Pp. 151-163 (13)
Abhishek Gour, Ashish Dogra, Utpal Nandi*

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Chromene and its Derivatives in the Treatment of SARS-COV- 2 Virus Infection

- Pp. 164-189 (26)
Dipti B. Ruikar, Karan Joshi, Rasana Yadav, Gajanan J. Deshmukh, Snehal Manekar, Prashant R. Murumkar*

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Chromenes as Anticancer Agents

- Pp. 190-214 (25)
Parul Grover, Harmandeep Kaur Gulati, Jasha Momo H. Anál, Debaraj Mukherjee*

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Chromene as Antioxidants

- Pp. 215-224 (10)
Rajeshwar Kamal Kant Arya*, Arun Kumar, Anchala Guglani, Dheeraj Bisht, Deepak Kumar

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The Implication of Chromene Derivatives in Bioactive Admixtures

- Pp. 225-234 (10)
Dheeraj Bisht*, Deepak Sati, Rajeshwar Kamal Kant Arya, Amit Kumar Nigam, Monu Kumar Shukla, Deepak Kumar

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Chromene Derivatives as Potassium Channel Openers or Inhibitors

- Pp. 235-244 (10)
Krittika Mukherjee, Vivek Panwar, Deepak Kumar Jindal, Sandeep Kumar, Isha Dhamija, Deepak Kumar*, Ashutosh Kumar Dash*

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Miscellany of Chromene

- Pp. 245-280 (36)
Partha Pratim Dutta, Faruk Alam*, Biplab Kumar Dey, Rajeev K. Tonk

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Subject Index

- Pp. 281-286 (6)
Ashutosh Kumar Dash, Deepak Kumar
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