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Alkaloids and Other Nitrogen-Containing Derivatives
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Editor: Simone Carradori

Series Title: Medicinal Chemistry Lessons From Nature

Alkaloids and Other Nitrogen-Containing Derivatives

Volume 3
eBook: US $79 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-5123-68-5 (Print)
ISBN: 978-981-5123-67-8 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151236781230301
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Introduction

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Volume 3 presents (1) a brief overview of botanical and pharmacological properties of alkaloids, (2) a summary of the synthesis of natural morphinans and related alkaloids, (3) caffeine-based compounds for the treatment of neurodegenerative disorders, (4) piperine derivatives, (5) noscapine-based anti-cancer agents, (6) biogenic amines and amino acid derivatives as carbonic anhydrase modulators and (7) antimalarial compounds on quinoline scaffolds.

The objective of this book is to fulfill gaps in current knowledge with updated information from recent years. It serves as a guide for academic and professional researchers and clinicians.


eBook: US $79 Special Offer: US $126 Printed Copy: US $87 Library License: US $316

Contributors

Editor(s):
Simone Carradori
Department of Pharmacy
G. d Annunzio University of Chieti-Pescara
Italy



Contributor(s):
Adriana Trifan
Department of Pharmacognosy, Faculty of Pharmacy
Grigore T. Popa University of Medicine and Pharmacy Iasi
16 Universitatii Street, 700115 Iasi
Romania


Alessandra Ammazzalorso
Department of Pharmacy, Medicinal Chemistry Unit
G. d Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy


Alessandro Bonardi
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Alessio Nocentini
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Andrea Angeli
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U.
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Annabella Vitalone
Department of Physiology and Pharmacology V. Ersparmer
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Antonella Capperucci
Department of Chemistry Ugo Schiff
University of Florence
Via della Lastruccia 13, I-50019 Sesto Fiorentino
Italy


Antonella Di Sotto
Department of Physiology and Pharmacology V. Ersparmer
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Arafa Musa
Department of Pharmacognosy
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Atilla Akdemir
Computer-aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy
Bezmialem Vakif University
Fatih, Istanbul 34093
Turkey


Barbara De Filippis
Department of Pharmacy
G. d Annunzio University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti
Italy


Bijo Mathew
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India


Celeste De Monte
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Claudio Ferrante
Department of Pharmacy, Medicinal Plant Unit (MPU), Botanic Garden Giardino dei Semplici
G. d Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy


Claudiu T. Supuran
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Pharmaceutical and Nutraceutical Section
University of Florence
Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Cristina Scarpecci
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Damiano Tanini
Department of Chemistry Ugo Schiff
University of Florence
Via della Lastruccia 13, I-50019 Sesto Fiorentino
Italy


Della Grace Thomas Parambi
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Dibya Sundar Panda
Department of Pharmaceutics, Faculty of science
Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Edeildo F. Silva-Júnior
Laboratory of Medicinal Chemistry
Pharmaceutical Sciences Institute, Federal University of Alagoas
Maceió
Brazil


Emanuela Berrino
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Pharmaceutical and Nutraceutical Section
University of Florence
Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Fabrizio Carta
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Pharmaceutical and Nutraceutical Section
University of Florence,
Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Federico Appetecchia
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Federico De Paolis
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Francesco Cairone
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Geraldo J. S. Neto
Group of Catalysis and Chemical Reactivity
Chemistry and Biotechnology Institute, Federal University of Alagoas
Maceió
Brazil


Giacomo Di Matteo
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Giovanna Poce
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Grazia Luisi
Department of Pharmacy
G. d Annunzio University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti
Italy


Heiko Lange
Department of Environmental and Earth Sciences
University of Milano-Bicocca
Milan
Italy


Igor J. S. Nascimento
Institute of Chemistry and Biotechnology, Federal University of Alagoas
Maceió
Brazil


João X. Araújo-Júnior
Institute of Chemistry and Biotechnology, Federal University of Alagoas
Maceió
Brazil


Jordan Trilli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Laura Di Muzio
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Leena K Pappachen
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India


Luc Zongo
Department of Pharmacy
University of Saint Dominic of West Africa (USDAO)
Doulougou
Burkina Faso


Luigi Menghini
Department of Pharmacy, Medicinal Plant Unit (MPU)
Botanic Garden Giardino dei Semplici, G. d Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy


Mohamed A. Abdelgawad
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Manoj Kumar Sachidanandan
Department of Oral and maxillofacial surgery and diagnostics
College of Dentistry, Hail University
Hail Province, 2440
Saudi Arabia


Marco Gullì
Department of Physiology and Pharmacology V. Ersparmer
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Maria Antonietta Casadei
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Marialuigia Fantacuzzi
Department of Pharmacy
G. d Annunzio University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti
Italy


Mariangela Biava
Department of Drug Chemistry and Technology
Sapienza, University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Mario R. Meneghetti
Institute of Chemistry and Biotechnology, Federal University of Alagoas
Maceió
Brazil


Mattia Spano
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Melissa D’Ascenzio
D’Arcy Thompson Unit, Biological and Biomedical Sciences Education
School of Life Sciences, University of Dundee
DD1 4HN, Dundee
UK


Mutairah Shaker Alshammari
Department of Pharmaceutical Analytical Chemistry, Faculty of science
Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Nathalie Saraiva Rosa
Department of Chemistry
Royal College of Surgeons in Ireland
Dublin
Ireland


Niccolò Chiaramonte
Department of Chemistry
Royal College of Surgeons in Ireland
Dublin
Ireland


Özlen Güzel-Akdemir
Department of Pharmaceutical Chemistry, Faculty of Pharmacy
Istanbul University
Beyazit, 34116 Istanbul
Turkey


Paolo Guglielmi
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Patrizia Paolicelli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Paulo F. Silva Santos-Júnior
Institute of Chemistry and Biotechnology
Federal University of Alagoas
Maceió
Brazil


Rafael J. M. Omena
Group of Catalysis and Chemical Reactivity
Chemistry and Biotechnology Institute, Federal University of Alagoas
Maceió
Brazil


Rania Bakr
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Sara Consalvi
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Silvia Di Giacomo
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Simone Carradori
Department of Pharmacy
G. d Annunzio University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti
Italy


Stefania Cesa
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Stefania Garzoli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Stefania Petralito
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Thiago M. Aquino
Institute of Chemistry and Biotechnology, Federal University of Alagoas
Maceió
Brazil


Trond Vidar Hansen
Department of Pharmacy
Section for Pharmaceutical Chemistry, University of Oslo
PO Box 1068 Blindern, N-0316 Oslo
Norway


Virginia Pontecorvi
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Vaishnav Bhaskar
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India