Editor: Simone Carradori

Series Title: Medicinal Chemistry Lessons From Nature

Terpenes

Volume 2

eBook: US $79 Special Offer (PDF + Printed Copy): US $133
Printed Copy: US $93
Library License: US $316
ISSN: 2972-3396 (Print)
ISSN: 2972-340X (Online)
ISBN: 978-981-5123-65-4 (Print)
ISBN: 978-981-5123-64-7 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151236471230201

Introduction

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Volume 2 gives (1) a detailed overview of the sesquiterpenes polypharmacology, (2) an interesting journey around the world of cannabinoids that reveals the development of new synthetic Δ9-THC derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generations of endoperoxides endowed with antimalarial activity and finally (5) a summary of MedChem strategies to fix the most common issues in formulating terpene derivatives (like low potency and poor solubility).

The objective of this book set is to fulfill gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

Contributors

Editor(s):
Simone Carradori
Department of Pharmacy
G. d Annunzio University of Chieti-Pescara
Italy




Contributor(s):
Annabella Vitalone
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Antonella Di Sotto
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Federico De Paolis
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Grazia Luisi
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara, via dei Vestini 31
66100 Chieti
Italy


Jordan Trilli
Department of Drug Chemistry and Technologies
Sapienza University of Rome, P.le A. Moro 5, 00185
Rome
Italy


Laura Di Muzio
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Marco Gullì
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Maria Antonietta Casadei
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Nathalie Saraiva Rosa
Royal College of Surgeons in Ireland
Department of Chemistry
Dublin
Ireland


Niccolò Chiaramonte
Royal College of Surgeons in Ireland
Department of Chemistry
Dublin
Ireland


Patrizia Paolicelli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Silvia Di Giacomo
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Stefania Petralito
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Stefania Garzoli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy