Editor: Simone Carradori

Series Title: Medicinal Chemistry Lessons From Nature


Volume 2

eBook: US $79 Special Offer (PDF + Printed Copy): US $133
Printed Copy: US $93
Library License: US $316
ISSN: 2972-3396 (Print)
ISSN: 2972-340X (Online)
ISBN: 978-981-5123-65-4 (Print)
ISBN: 978-981-5123-64-7 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151236471230201


Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Volume 2 gives (1) a detailed overview of the sesquiterpenes polypharmacology, (2) an interesting journey around the world of cannabinoids that reveals the development of new synthetic Δ9-THC derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generations of endoperoxides endowed with antimalarial activity and finally (5) a summary of MedChem strategies to fix the most common issues in formulating terpene derivatives (like low potency and poor solubility).

The objective of this book set is to fulfill gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.


- Pp. i-ii (2)
Ilaria D’Agostino*
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- Pp. iii
Simone Carradori*
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List of Contributors

- Pp. iv

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Sesquiterpenes: A Terpene Subclass with Multifaceted Bioactivities

- Pp. 1-55 (55)
Antonella Di Sotto*, Federico De Paolis, Marco Gullì, Annabella Vitalone, Silvia Di Giacomo

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From Δ9-THC to Synthetic Cannabinoids: Multi- Faceted Therapeutic Agents and Versatile Scaffolds for Drug Discovery

- Pp. 56-93 (38)
Niccolò Chiaramonte*, Nathalie Saraiva Rosa*

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Encapsulation of Essential Oils within Lipid-Based Formulations for Enhanced Antimicrobial Activity

- Pp. 94-157 (64)
Patrizia Paolicelli*, Stefania Petralito, Jordan Trilli, Laura Di Muzio, Stefania Garzoli, Maria Antonietta Casadei

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Antimalarial Endoperoxides: from Natural Sesquiterpene Drugs to a Rising Generation of Synthetic Congeners

- Pp. 158-227 (70)
Grazia Luisi*

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Subject Index

- Pp. 228-237 (10)

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