Preface

Studying brain physiology and development is a leading neuroscience strategy not only to illuminate the general understanding of brain structure and function but also to make progress against neurodegenerative disorders that are devastating the healthy aging.

The volume 11 of our book series Frontiers in Clinical Drug Research - CNS and Neurological Disorders introduces the subject of neurodegeneration by outlining the pathophysiology genetics, and environmental factors. This book besides providing a clear overview of the neurodegeneration and addiction process also introduces the readers to a new synthesis of ideas. To contextualize the research for the general readers, it also provides a brief introduction to the pharmacological and non-pharmacological approaches to treat the commonest neurodegenerative and addictive disorders. This book takes interested beginners on a journey from a cold start to a grasp of neuroscience’s best line of research. The current volume integrates the work of neurobiologists into a coherent account of the nature of neurodegenerative and addictive disorders and their treatment.

For instance, Chapter 1 highlights the multi-target directed ligands candidate prototypes inspired mostly by natural products to treat some of the most studied diseases, namely, Parkinson’s Disease, Alzheimer’s Disease, and Huntington’s Disease, as well as amyotrophic lateral sclerosis. Chapter 2 discusses the role of psychological and neurological factors as well as genetics and neurobiological mechanisms to review the drugs used for relapse prevention to treat addiction to nicotine, alcohol, or illicit drugs. Chapter 3 summarizes the neuroprotective properties of cinnamic acids and their derivatives in light of their mechanistic aspects to treat various neurodegenerative disorders. Chapter 4 reviews the role of phytosome in the targeted delivery of natural compounds across the blood brain-barrier to improve the efficacy, and bioavailability of Alzheimer's drugs. Chapter 5 glances at clinical trials investigating non-pharmacologic approaches, such as physical activity to improve the symptoms of Alzheimer’s Disease.

Briefly, this volume is the definitive guide to common neurodegenerative diseases that affect humans. The book covers the mechanisms of some of the most well-known neurodegenerative and addictive diseases, their biomarkers, neuropharmacology, and emerging treatment strategies.

We are grateful for the timely efforts made by the editorial personnel, especially Mr. Mahmood Alam (Director Publications), and Ms. Asma Ahmed (Senior Manager Publications) at Bentham Science Publishers.