Foreword

Human diseases especially genetic disabilities have always been a focus of research. Research on genetics and molecular genetics has contributed extensively to improving the overall quality of life and management of patients suffering from genetic diseases. With the onset of Omics and Next generation technologies (NGS), the dream of personalized medicine has almost come to reality. Technological advances in the domains of genomics, transcriptomics, proteomics and metabolomics have enabled scientists to explore the genetic and molecular causes in extraordinary detail. These technologies have contributed immensely to advancements related to early and efficient diagnosis, which have revolutionized clinical practices. Despite the contribution of these technologies, it is always felt that none of these technologies alone have the potential to cope with the biological complexity of human diseases. The integration of multiple technologies and a combination of diverse data types is the new approach that has the potential to provide a more comprehensive understanding of biological systems controlling the onset, progression and impact of diseases.

Initially, the focus of research has been on the early diagnosis and methods by which the symptoms of the disease could be eased off. Gene Therapy, personalized medicine, and precision medicine are very promising concepts but there have always been concerns about the access of the general public to these approaches as well as the application for diverse genetic diseases including rare and common diseases, multifactorial diseases including cancers. Omics Technologies have not only provided the scientists with better opportunities for correct diagnosis but also expanded the options for treatment including gene therapy, pharmacogenomics, single-cell omics, regenerative medicine, stem cell technologies and many more. Integrative approaches utilizing engineering and informatics have also widened the knowledge base required for appropriate treatment and management approaches.

This book compiled and edited by scientists working in various domains of genomics and human genetics will not only provide the researchers with new approaches in conventional methods of genetics-based diagnosis and counselling but will also open new avenues for further exploration of genetic causes and treatment options. This book is a great effort to document state-of-the-art techniques and technologies for disease prediction and early diagnosis to disease treatment and prognosis using integrative Omics.