Editors: Dilvani Oliveira Santos, Paulo Renato Zuquim Antas

Series Title: Frontiers in Inflammation

Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases

Volume 3

eBook: US $39 Special Offer (PDF + Printed Copy): US $72
Printed Copy: US $52
Library License: US $156
ISSN: 2468-1466 (Print)
ISSN: 2468-1474 (Online)
ISBN: 978-981-5051-70-4 (Print)
ISBN: 978-981-5051-69-8 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150516981220301

Introduction

Mitochondria are multifunctional organelles that actively participate in the immune-inflammatory response in various pathologies. This volume updates readers on knowledge about mitochondria function. The editors have compiled six chapters about inflammation in its broadest sense, with contributions from active groups of cell biologists, infectologists and pathologists.

The chapters in this volume focus on research related to five notable diseases:

(1) two diseases (one bacterial and one viral) in which the exacerbation of the inflammatory response can lead to neuropathies: leprosy (one of the oldest diseases in the world) and Zika fever (a disease relatively new in Brazil)

(2) three diseases (two bacterial and one viral) in which the exacerbation of the inflammatory response can lead to irreversible lung damage that can cause rapid death: tuberculosis, pneumonia and the most recent global disease, COVID- 19.

New information about mitochondrial biology is presented, such as the effect of aerobic physical exercise as a stimulator for mitochondria multiplication, and the role of mitochondrial damage in inducing immune-inflammatory responses to pathogens. The contents shed light on mitochondrial biochemical pathways that could serve as potential therapeutic targets.

This is an important reference for scholars (cell biologists, microbiologists) in universities, hospitals and scientific research centers working on biological and biomedical problems, and for health professionals involved in infection control.

Audience: Scholars (cell biologists, microbiologists) in universities, hospitals and scientific research centers working on biological and biomedical problems; health professionals involved in infection control.

Foreword

- Pp. i
Cintia de Moraes Borba
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Preface

- Pp. ii-iii (2)
Dilvani Oliveira Santos, Paulo Renato Zuquim Antas
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Dedication

- Pp. iv
Dilvani Oliveira Santos, Paulo Renato Zuquim Antas
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List of Contributors

- Pp. v-vi (2)
Dilvani Oliveira Santos, Paulo Renato Zuquim Antas
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An Auspicious Bacterium: How Mitochondria can be Beneficial to the Innate Immunity through Aerobic Exercises

- Pp. 1-21 (21)
Dilvani Oliveira Santos*, Arthur Willkomm Kazniakowski, Anna Fernandes Silva Chagas do Nascimento, Laura Brandão Martins, Sourou Credo Francisco Justus Zinsou, Rodolfo Avila, Maria Elena Samar

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Mitochondrial Dysfunction in Leprosy: Shedding Light on the Neurodegenerative Consequences

- Pp. 22-53 (32)
Dilvani Oliveira Santos*

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The Multifaceted Interface Between the Host Immune Cell and Mycobacterium Tuberculosis - Mitochondria at the Crux of the Matter

- Pp. 54-70 (17)
Dilvani Oliveira Santos*, Paulo Renato Zuquim Antas

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Mitochondrial DNA and Streptococcus pneumoniae Infection – Induction of Immuno-inflammatory Response

- Pp. 71-85 (15)
Felipe Piedade Gonçalves Neves*, Alessandra D` Almeida Filardy, Tatiana de Castro Abreu Pinto

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Mitochondrial DNA Role in Zika Virus Infection

- Pp. 86-100 (15)
Fabiana Rabe Carvalho, Débora Familiar-Macedo, Andrea Alice Silva*

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Mitochondrial Dysfunction and the Immuno-inflammatory Response Induced by SARS-CoV-2 Infection: the Role of Mitochondrial DNA

- Pp. 101-123 (23)
Thalia Medeiros, Analúcia Rampazzo Xavier, Andrea Alice Silva*

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Subject Index

- Pp. 124-134 (11)
Dilvani Oliveira Santos, Paulo Renato Zuquim Antas
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