Editor: Rajesh Kumar Singh

Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I

eBook: US $79 Special Offer (PDF + Printed Copy): US $145
Printed Copy: US $105
Library License: US $316
ISBN: 978-981-5040-08-1 (Print)
ISBN: 978-981-5040-07-4 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150400741220101


This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design.

Part 1 of the book set covers these topics:

  • - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action
  • - The role of terpenoids as anticancer compounds: an insight into prevention and treatment
  • - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents
  • - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents
  • - Tetrazoles: structure and activity relationship as anticancer agents
  • - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)


Cancer is a blemish on the face of humanity in this age of science and technology. While significant progress has been made in the treatment of cancer over the last 50 years, it remains a serious public health concern, necessitating extensive research into new therapeutic approaches. Despite the availability of a number of anticancer medications, problems like multidrug resistance, less therapeutic efficacy, solubility, undesirable side effects, and/or low bioavailability necessitate the creation of novel anticancer treatments. Because of their outstanding pharmacological activity, particularly their anticancer characteristics, heterocyclic compounds have been the primary molecules in organic chemistry for more than a century.

This book entitled 'Key Heterocyclic Cores for Smart Anticancer Drug-Design' is a detailed assessment of some of the most intriguing hot topics for developing novel anticancer chemotherapeutics. This book aims to help readers quickly grasp the biological targets, structure-activity relationship (SAR), existing problems, and future prospects of heterocyclic- based anticancer medicines.

I'm really enthusiastic about this book and looking forward to its publication at the earliest possible. This book serves as a resource for health care providers, researchers, academicians, and medicinal chemists. The authors and Bentham publishers deserve praise for delivering timely and relevant information.

Raj Kumar, Ph.D., FRSC
Department of Pharmaceutical Sciences and Natural Products
Central University of Punjab
Bathinda 151 401,
Punjab, India