Editors: Pankaj Kumar Singh, Dharmendra Kumar Khatri, Shashi Bala Singh, Anitha Sriram

An Update on SARS-CoV-2: Damage-response Framework, Potential Therapeutic Avenues and the Impact of Nanotechnology on COVID-19 Therapy

eBook: US $79 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-5039-87-0 (Print)
ISBN: 978-981-5039-86-3 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150398631220101


This update on SARS-CoV-2 focuses on basic knowledge about the virus and COVID-19 treatment. Chapters present basic information about the disease and its treatment. The virology, epidemiology, etiology, and damage response framework of SARS-CoV-2 are also discussed in detail.

The book also covers recent topics of interest to pharmacology scholars such as the immunopathogenesis of SARS-CoV2, nanotechnology, repurposed drug treatments, COVID-19 vaccines, and phytomedicine for COVID-19 therapeutics.

Readers in pharmacology, virology and medicine will find the book a simple, yet informative update on SARS-CoV-2 and COVID-19 treatment.


The authors were inspired to write this book by a vision to provide the basic and core information regarding the novel and life-threatening coronavirus namely 2019-nCoV causing COVID-19, of which the entire world was completely unaware.

The COVID-19 pandemic outbreak has evidenced us to be an astounding catastrophe inflicting billions of lives around the globe. To date, it was reported that the third highly pathogenic human Coronavirus disease is COVID-19, which has posed a severe and serious threat to the entire world's socioeconomic, medical, and public health infrastructure.

Considering the present scenario, this book contains eleven chapters on different aspects related to COVID-19 and 2019-nCoV summarising what we have hitherto learned in the following key areas of virology, epidemiology, aetiology, damage response framework, pathophysiology, and diagnosis of COVID-19.

Several candidate-repositioning drugs have been proven with a record of both safety as well as efficacy profiles which have been widely used in some countries during the pandemic situation against 2019nCoV. Due to their pharmacological role and mechanism of action, some phytopharmaceuticals and immunomodulators are efficacious against 2019-nCoV and might be finding potential to combat COVID-19; all of which are discussed in this book in detail. This book also provides deep insights into the repurposed drugs, pharmaceutical intervention strategies, various treatments, clinical and research approaches, all authorised vaccines and nanotechnology tools that may fill the research gaps for the current COVID-19 management and future pandemic outbreaks of newly emerging 2019-nCoV variants.

To manage COVID-19 and curb the global spread of 2019-nCoV, knowledge of all of the above aspects is required. Hence, we compiled all of these elements into one book as separate chapters to present a valuable resource of information on COVID-19 for all of those who are involved in this coronavirology field.

This book in essence provides a grass-root level of knowledge about COVID-19 and 2019-nCoV. It is also a manual to guide future coronavirology scientists assisting them with future research ideas and approaches to combat new variants of 2019-nCoV as well as future outbreaks of coronaviruses.

We hope that you enjoy this book and find it useful.

Pankaj Kumar Singh
Department of Pharmaceutics,
National Institute of Pharmaceutical
Education and Research,
(NIPER) Hyderabad, 500037,

Dharmendra Kumar Khatri
Department of Pharmacology
and Toxicology National Institute
of Pharmaceutical Education
and Research, (NIPER)
Hyderabad, 500037, India

Anitha Sriram
National Institute of Pharmaceutical
Education and Research (NIPER),
40, Dilip Rd, Jinkalwada,
Balanagar, Hyderabad,
Telangana, India


Shashi Bala Singh
Department of Biological Sciences,
National Institute of Pharmaceutical
Education and Research,
(NIPER) Hyderabad, 500037,