Editor: Anil Kumar, Kanwaljit Chopra, Anurag Kuhad, Sangeeta Pilkhwal Sah & Sandip V Pawar

Animal Models for Neurological Disorders

eBook: US $69 Special Offer (PDF + Printed Copy): US $117
Printed Copy: US $83
Library License: US $276
ISBN: 978-981-5039-69-6 (Print)
ISBN: 978-981-5039-68-9 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150396891210101

Introduction

Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule.

Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate.

Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

Audience: Scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, biotechnology; scientists working in applied areas of experimental pharmacology, neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

Foreword

Drug discovery and drug development nowadays are growing very fast by using new tools and advanced techniques of modern science. Drugs are being synthesized or obtained from natural sources, including marine sources, to get lead molecules. Every such molecule needs to be evaluated in terms of safety and efficacy before it is actually being used for mankind.

Animal models are a basic essential tool to prove the safety and efficacy of any drug molecule in experimental neuroscience. Therefore, the selection of a suitable and reliable experimental model becomes essential. Every experimental model has its own potential advantages and limitations in order to study disease pathologies, and therefore, increasingly, various emerging tools and techniques are being used in addition to it. It becomes imperative for every researcher to be able to select suitable animal models and have an in-depth knowledge of their advantages or limitations while studying disease pathologies.

I am confident that the present book serves the purpose of various researchers working in the areas of neurological problems, in particular Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, autism, etc., to understand the various aspects of these experimental models and their potential use to study disease pathologies. The present book has been written with a purpose to provide various key insights related to pathophysiology, experimental (invivo and invitro) techniques, advantages, disadvantages, limitations, including future prospective of various experimental models such as Alzheimer, depression, psychosis, Parkinson, vascular dementia, multiple sclerosis, schizophrenia, autism, Huntington disease and brain tumor model based on researcher’s laboratory experience. Biomedical researchers will further benefit from the rich research experiences of the authors working in the areas of neurological problems. Lastly, I would like to commend Prof. Anil Kumar on this brilliant effort.

Dr. Gautam Palit
M.D.(Lko)., M.A.M.S., F.C.C.P.(U.S.A.)., F.C.A.I., F.I.A.N., F.I.P.S.
Ex.Head, Division of Pharmacology & Senior Deputy Director ( Scientist-“G”)
Central Drug Research Institute (CDRI), Lucknow
Presently Professor and Head, Department of Pharmacology,
Saraswati Dental College & Hospital, Lucknow.

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