Editors: Biaoru Li, Alan Larson, Shen Li

Personalized Immunotherapy for Tumor Diseases and Beyond

eBook: US $79 Special Offer (PDF + Printed Copy): US $128
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-14-8273-1 (Print)
ISBN: 978-981-14-8275-5 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114827551200101

Introduction

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology.

Key Features:

- Introduces readers to basic concepts in personalized medicine and immunotherapy

- Presents current information about immunological assays used in research

- Presents an overview of T cell immunotherapy and cloning techniques

- Presents an overview of tumor cell bioinformatics and its role in immunotherapy

- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling)

- Includes a section on biobanking

- Presents information in an easy-to-read format for a wide range of readers

- Brings contributions from experts with over 30 years of experience in personalized immunotherapy

Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

Contributors

Editor(s):
Biaoru Li


Alan Larson


Shen Li




Contributor(s):
Alan Larson
Department of Virology
Chicago
USA


Amit Datta
Department of Biochemistry
Case Western Reserve University School of Medicine
Cleveland
USA


Biaoru Li
Department of Biochemistry
Case Western Reserve University School of Medicine
Cleveland
USA
/
Department of Pediatrics
Medical College at GA
Augusta
USA


Baoyu Wu
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Deyuan Lu
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Emmanuelle Devemy
Rush Cancer Institute
Chicago
USA


George E. Liu
Department of Biochemistry
Case Western Reserve University School of Medicine
Cleveland
USA
/
Beltsville Agricultural Research Center (BARC) – East
Beltsville
USA


GuanXiang Qian
Department of Biochemistry
Shanghai Second Medical University
Shanghai
China


Hong-Liang Hu
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


JianQing Ding
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Jie Zheng
Department of Microbiology
School of Computer Engineering
Singapore


Li-Hua Jiang
Departments of Immunology and Microbiology
Shanghai Jiao Tong University School of Medicine
Shanghai
China


Meihua Lin
Department of Biochemistry
Case Western Reserve University School of Medicine
Cleveland
USA


Shanqing Tong
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Shen Li
Division of Surgical Oncology
Boston
USA


Shishu Chen
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Supriya Perabekam
Rush Cancer Institute
Chicago
USA


Shuzhen Tan
Guangdong Medical University
Zhanjiang
China


Wei-Hua Yan
Medical Research Center
enzhou Medical University
China


Wei Zhang
Department of Biochemistry
Case Western Reserve University School of Medicine
Cleveland
USA


Xihan Zhang
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Xiao Zhu
Guangdong Medical University
Zhanjiang
China


Youming Zhu
Department of Microbiology
Shanghai Second Medical University
Shanghai
China


Yan Qu
Department of Biochemistry
Case Western Reserve University School of Medicine
Cleveland
USA




RELATED BOOKS

.Natural Immunomodulators: Promising Therapy for Disease Management.
.Herbal Immunity Boosters Against COVID-19.
.Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases.
.Frontiers in Clinical Drug Research – Anti Allergy Agents.