Editors: Biaoru Li, Alan Larson, Shen Li

Personalized Immunotherapy for Tumor Diseases and Beyond

eBook: US $79 Special Offer (PDF + Printed Copy): US $128
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-14-8273-1 (Print)
ISBN: 978-981-14-8275-5 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114827551200101

Introduction

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology.

Key Features:

- Introduces readers to basic concepts in personalized medicine and immunotherapy

- Presents current information about immunological assays used in research

- Presents an overview of T cell immunotherapy and cloning techniques

- Presents an overview of tumor cell bioinformatics and its role in immunotherapy

- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling)

- Includes a section on biobanking

- Presents information in an easy-to-read format for a wide range of readers

- Brings contributions from experts with over 30 years of experience in personalized immunotherapy

Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

Preface

- Pp. i-v (5)
Biaoru Li
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List of Contributors

- Pp. vi-vii (2)
Biaoru Li
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Introduction

- Pp. viii
Biaoru Li
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MHC and Cancer Immunotherapy

- Pp. 1-19 (19)
Li-Hua Jiang and Wei-Hua Yan

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Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy

- Pp. 20-42 (23)
Wei Zhang, Yan Qu, Meihua Lin, Amit Datta, George E. Liu and Biaoru Li

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Immunoassay of Personalized Immunotherapy

- Pp. 43-56 (14)
Li-Hua Jiang and Biaoru Li

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Tumor Microenvironment, ADO/IDO Pathway- Foundation of Personalized Immunotherapy

- Pp. 57-69 (13)
Xiao Zhu, Li-Hua Jiang and Biaoru Li

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Molecular Targeting Checkpoint in Cancer- Foundation of Personalized Immunotherapy

- Pp. 70-79 (10)
Shuzhen Tan and Xiao Zhu

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Molecular Screening and Neoantigen Cloning- Fundamental of Adoptive T-cell Immunotherapy

- Pp. 80-96 (17)
Wei Zhang, George Liu, Emmanuelle Devemy and Biaoru Li

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Primary Cell Culture and T-cell Cloning - Fundamental of Adoptive T-cell Immunotherapy

- Pp. 97-117 (21)
Biaoru Li, Supriya Perabekam, Alan Larson and Hong-Liang Hu

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Bioinformatics of T-cell and Primary Tumor Cells- Fundamental of Adoptive T-cell Immunotherapy

- Pp. 118-136 (19)
George Liu, Jie Zheng and Biaoru Li

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Development of Adoptive T-cell Immunotherapy- Future of Personalized Immunotherapy

- Pp. 137-159 (23)
Biaoru Li, Shanqing Tong, Xihan Zhang, Youming Zhu, Baoyu Wu and Deyuan Lu

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Gene Therapy and Genomic Editing-Development of Adoptive T-cell Immunotherapy

- Pp. 160-173 (14)
JianQing Ding, GuanXiang Qian, Shishu Chen and Biaoru Li

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Genetically Modified T-cells Affinity to Tumor Cells-Development of Adoptive T-cell Immunotherapy

- Pp. 174-196 (23)
Shen Li, Supriya Perabekam, Emmanuelle Devemy and Biaoru Li

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System Modeling of T-cell Function-Development of Adoptive T-cell Immunotherapy

- Pp. 197-223 (27)
Biaoru Li, George Liu and Jie Zheng

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Biobank for Personalized Immunotherapy

- Pp. 224-254 (31)
Biaoru Li

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Subject Index

- Pp. 255-264 (10)
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