Editors: Shankar Suman, Garima Suman, Sanjay Mishra

Current Advances in Breast Cancer Research: A Molecular Approach

eBook: US $99 Special Offer (PDF + Printed Copy): US $168
Printed Copy: US $119
Library License: US $396
ISBN: 978-981-14-5142-3 (Print)
ISBN: 978-981-14-5144-7 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114514471200101

Introduction

Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease.

Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.

Foreword

Breast cancer is the leading cause of cancer for women both in the developed and the developing world, as per the World Health Organization. Breast cancer also affects men. Over a decade, cancer incidence has declined, but breast cancer incidence in females has increased by 0.4% per year. Although advancements in breast cancer screening, preventive measures, and treatment have resulted in a significant decline in breast cancer mortality, breast cancer still is the second most common cause of cancer-related deaths in females. Unacceptable levels of racial disparity have been consistently reported in breast cancer and offer a challenge in breast cancer prevention, detection, and cure. These disparities are independent of socioeconomic status, access to healthcare or age, or even the stage of breast cancer. Among the major challenges, the heterogeneity in cancer cells makes the disease more complex. Researchers have made significant advancements in studying the heterogenic features in breast cancer, and multiple subsets of breast cancer are discovered. In the molecular biology studies, breast cancer stem-like cells, driver mutations and changes in the tumor microenvironment are investigated as a potential hallmark for the disease progression. The “Omics” approaches in cancer research brought a detailed understanding of breast cancer at a new height. This technology is highly promising in discovering novel biomarkers in different breast cancer subtypes. Genomics, transcriptomics, proteomics, metabolomics, and other omics platforms have opened a new avenue to discover molecular insights in cancer progression. Immunological aspects of breast cancer are considered as cutting-edge science in recent discoveries. This book brings together up-to-date information to address the various challenging aspects of breast cancer. I congratulate the editors for putting together the different pieces of findings of breast cancer research in this book. I hope “Current advances in Breast cancer Research: A molecular approach” will be a good addition to the library of breast cancer literature.

Dr. Smita Misra
School of Graduate Studies and Research,
Centre for Women’s Health Research (CWHR),
Meharry Medical College,
Nashville,
TN
USA


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