Editors: Atta-ur-Rahman, FRS , M. Iqbal Choudhary

Anti-Angiogenesis Drug Discovery and Development

Volume 5

eBook: US $119 Special Offer (PDF + Printed Copy): US $190
Printed Copy: US $131
Library License: US $476
ISSN: 2452-3240 (Print)
ISSN: 2210-268X (Online)
ISBN: 978-981-14-3286-6 (Print)
ISBN: 978-981-14-3287-3 (Online)
Year of Publication: 2020
DOI: 10.2174/97898114328731200501


The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

The fifth volume brings together reviews on the following topics:

  • - Targeted therapy for tumor vasculature
  • - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials)
  • - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents


- Pp. i-ii (2)
Atta-ur-Rahman and M. Iqbal Choudhary
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List of Contributors

- Pp. iii-iv (2)
Atta-ur-Rahman and M. Iqbal Choudhary
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Therapeutic Targeting of the Tumor Vasculature: Past, Present and Future

- Pp. 1-29 (29)
Peace Mabeta, Mike Sathekge and Vanessa Steenkamp

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Anti-angiogenic Mechanism, Biochemical Factors’ Roles, Therapeutic Agents, and Under Clinical Trial Drugs for Breast and Prostate Cancers

- Pp. 30-85 (56)
Varsha M. Singh, Shilpa J. Newati, Mohammad Yusuf, Alexandre Bridoux, Salman A. A. Mohammed, Naseem Akhtar and Riaz A. Khan

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Microbe-based Antiangiogenesis Therapies for Cancer Management

- Pp. 86-124 (39)
Samman Munir, Usman Ali Ashfaq, Asad Ali Shah, Muhammad Shahid, Muhammad Sajid Hamid Akash and Mohsin Khurshid

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Novel Anti-angiogenic Strategies in Cancer Drug Development

- Pp. 125-150 (26)
Hoorieh Soleimanjahi and Ala Habibian

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Angiogenesis and Chromene-based Antiangiogenic Therapeutic Agents

- Pp. 151-188 (38)
Olivia Pontes, Ana Raquel-Cunha, Sofia Oliveira-Pinto, Fatima Baltazar, Olga Martinho and Marta Costa

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Subject Index

- Pp. 189-198 (10)
Atta-ur-Rahman and M. Iqbal Choudhary
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